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- W3142621509 abstract "BACKGROUND OBJECTIVE: Flavonoids, with some beneficial biological activities, exist extensively in foods and herbal products. This study was to evaluate the effects of 23 flavonoids on the proliferation of leukemia cell line HL-60, and elucidate the structure-activity relationship (SAR). METHODS: HL-60 cells were treated with 23 flavonoids with high purity and definite structure. Cell proliferation was detected by MTT assay. The 50% inhibition concentrations (IC50) of the 23 flavonoids were calculated. The effects of particular structures on IC50 were evaluated. RESULTS: Most of the 23 flavonoids inhibited the proliferation of HL-60 cells distinctly, and the effects were enhanced along with increasing concentrations. However, the intensity of their effects were different, which were arranged from strong to weak as follows:3,6-dihydroxyflavone luteolin geraldol 2′-hydroxyflavanone apigenin 3,7-dihydroxyflavone myricetin fisetin baicalein quercetin flavanone chrysin galangin 4′-hydroxyflavanone 6-hydroxyflavone genistein flavone 7-hydroxyflavone daidzein hesperetin naringenin. The 2,3-double bond in ring C, appropriate hydroxyls, ring B attached at position 2, hydroxyls in position 3, ortho-substituting hydroxyls in ring B were related to enhanced inhibitory effects of flavonoids on the proliferation of HL-60 cells, while the lack of 2,3-double bond, deficiency or redundancy of hydroxyl groups, hydroxyl group in position 5, 7 or meta-substituting hydroxyls in ring B, isoflavone structure were related to reduced inhibitory effects of flavonoids. CONCLUSION: The 2,3-double bond in ring C, appropriate hydroxyls, ring B attached at position 2, hydroxyls in position 3, ortho-substituting hydroxyls in ring B may be key structural requirements of flavonoids for potent cytotoxicity to HL-60 cells." @default.
- W3142621509 created "2021-04-13" @default.
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- W3142621509 date "2007-01-01" @default.
- W3142621509 modified "2023-09-25" @default.
- W3142621509 title "Effects of Flavonoids with Different Structures on Proliferation of Leukemia Cell Line HL-60" @default.
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