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- W3142645048 abstract "瞄准：为了在胆汁管评估，绑扎老鼠没有，是否有肾的功能的进步改变，在组织病理学说变化。方法：男 Wistar 老鼠被提交到假冒外科或胆汁管结扎(BDL ) 并且根据过程以后的时间划分了(2， 4 并且 6-wk ) 。决定肾的功能参数，老鼠被放在新陈代谢的笼子，在实验的结束，血和尿样品被获得。组织学和羟脯氨酸内容在肝和肾的组织被分析。结果：有 BDL 的 2 wk 的老鼠增加了游离水清理(P = 0.02 ) ，减少的尿 osmolality (P = 0.03 ) 并且浆液肌酸酐(P = 0.01 ) 与假冒的组相比。相反，在 BDL 的 6 wk 的老鼠显示出 HRS 的特征，包括浆液肌酸酐的重要增加和在 creatinine，水排泄和尿钠集中的减小。有 BDL 的 4 wk 的老鼠展出了肾的机能障碍的中间期。进步肝的纤维变性被组织学根据过程以后的时间证实。肝羟脯氨酸的增加的层次在肾与结构的变化的缺席形成对照，在肾的织物由组织学和未改变的羟脯氨酸内容估计了。结论：我们的数据证明没有结构的变化， BDL 在肾生产了进步肾的机能障碍，描绘 HRS。现在的模型将是有用的理解 HRS 的病理生理学。" @default.
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- W3142645048 date "2008-01-01" @default.
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- W3142645048 title "Development of hepatorenal syndrome in bile duct ligated rats" @default.
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