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- W3142688863 abstract "Objective To explore the effect of Jianpi Qinghua Recipe( JQR) on renal functions of adriamycin-induced focal segmental glomerular sclerosis( FSGS) rats from the angle of activating fibroblasts to myofibroblast( MyoF). Methods Totally 56 rats were randomly divided into the normal control group(n =8),the sham-operation group(n =8),and the model group(n =40). The FSGS rat model was induced by nephrectomy of left kidney plus intravenous injection of adriamycin. Successfully modeled rats were further divided into 5 groups,i. e.,the model group,the JQR group,the JPR( Jianpi Recipe)group,the QHR( Qinghua Recipe) group,and the NDQ( Niaoduqing) group,8 in each group. Corresponding drugs were administered to rats in all groups,2 mL each time,for 56 days. The effect of JQR on serum creatinine( SCr),urea nitrogen,24-h urinary protein excretion,α-smooth muscle actin( α-SMA) mRNA,collagen type Ⅲ( Col Ⅲ) mRNA,fibronectin( FN) mRNA,and collagen type Ⅳ( Col Ⅳ) mRNA were observed. Results JQR could significantly lower SCr,urea nitrogen,and 24-h urinary protein excretion levels(P 0. 01),and significantly decrease mRNA levels of α-SMA,Col Ⅲ,FN,and Col Ⅳ(P 0. 01). It was advantageous over the NDQ group. Compared with JPR,the relative expression levels of Col Ⅲ mRNA and FN mRNA of JQR and QHR were significantly lower(P 0. 01). Conclusions JQR could improve the renal function and renal fibrosis in the adriamycin-induced nephropathic model rats. Its efficacy was superior to that of NDQ. Its mechanisms might be linked with inhibiting activation of fibroblasts." @default.
- W3142688863 created "2021-04-13" @default.
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- W3142688863 date "2014-01-01" @default.
- W3142688863 modified "2023-09-25" @default.
- W3142688863 title "Effect and Mechanism of Jianpi Qinghua Recipe on Renal Functions of Adriamycin-induced Nephropathic Rats from the Angle of Inhibiting Renal Fibrosis" @default.
- W3142688863 hasPublicationYear "2014" @default.
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