FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3142733986> ?p ?o ?g. }

• W3142733986 endingPage "129857" @default.
• W3142733986 startingPage "129857" @default.
• W3142733986 abstract "As an ideal liquid biopsy biomarker candidate, circulating tumor DNA (ctDNA) plays an important role in the non-invasive diagnosis of cancer. Sensitive and precise analysis of ctDNA plays a vital role in promoting clinical applications. Herein, we have developed a novel electrochemical biosensor for ctDNA assay coupling wheel-like catalytic hairpin assembly (WCHA) and frame hybridization chain reaction (FHCR). The ctDNA bound to the DNA transducer by the toehold strand displacement and released the initiator to promote the recycle amplification of WCHA, which lead to the formation of a great number of wheel-like DNA products hybridized with the capture probes immobilized on the gold electrode surface. In addition, the metastable dumbbell probes (DSH1 and DSH2) are designed for hybridization chain reaction. Compared with the traditional HCR, this novel form of HCR (FHCR) can fold up more compact and dense DNA nanostructures, which greatly reduce the space potential resistance and enhance the electronic transmission ability. The combination of dual signal amplification strategies (WCHA/FHCR) significantly improve the sensitivity of ctDNA detection, creating a limit of detection (LOD) as low as 8.3 fM. More importantly, the proposed method is successfully applied in the analysis of clinical samples, and has an effective classifier with an AUC of 0.909, showing a sensitivity of 86.7 % and a specificity of 80.0 % for the diagnosis of breast tumors. Therefore, this platform has great potential in bioanalysis and clinical diagnostics." @default.
• W3142733986 created "2021-04-13" @default.
• W3142733986 creator A5010479257 @default.
• W3142733986 creator A5011248078 @default.
• W3142733986 creator A5046225712 @default.
• W3142733986 creator A5050874455 @default.
• W3142733986 creator A5057884992 @default.
• W3142733986 creator A5067749008 @default.
• W3142733986 creator A5068980726 @default.
• W3142733986 creator A5082117229 @default.
• W3142733986 creator A5085175356 @default.
• W3142733986 creator A5087284408 @default.
• W3142733986 creator A5091378966 @default.
• W3142733986 date "2021-07-01" @default.
• W3142733986 modified "2023-10-18" @default.
• W3142733986 title "An enzyme-free amplification strategy for sensitive assay of circulating tumor DNA based on wheel-like catalytic hairpin assembly and frame hybridization chain reaction" @default.
• W3142733986 cites W1975644564 @default.
• W3142733986 cites W1978861310 @default.
• W3142733986 cites W1983466841 @default.
• W3142733986 cites W1991581123 @default.
• W3142733986 cites W2008662133 @default.
• W3142733986 cites W2034996481 @default.
• W3142733986 cites W2056113491 @default.
• W3142733986 cites W2088164932 @default.
• W3142733986 cites W2104641188 @default.
• W3142733986 cites W2164421236 @default.
• W3142733986 cites W2258571437 @default.
• W3142733986 cites W2258935349 @default.
• W3142733986 cites W2280282117 @default.
• W3142733986 cites W2314186529 @default.
• W3142733986 cites W2315794092 @default.
• W3142733986 cites W2460931906 @default.
• W3142733986 cites W2502992426 @default.
• W3142733986 cites W2511420722 @default.
• W3142733986 cites W2516846277 @default.
• W3142733986 cites W2586862787 @default.
• W3142733986 cites W2620625960 @default.
• W3142733986 cites W2747823608 @default.
• W3142733986 cites W2766058117 @default.
• W3142733986 cites W2775829357 @default.
• W3142733986 cites W2801739254 @default.
• W3142733986 cites W2808933492 @default.
• W3142733986 cites W2810399835 @default.
• W3142733986 cites W2888543617 @default.
• W3142733986 cites W2892158054 @default.
• W3142733986 cites W3004744434 @default.
• W3142733986 cites W4235642752 @default.
• W3142733986 doi "https://doi.org/10.1016/j.snb.2021.129857" @default.
• W3142733986 hasPublicationYear "2021" @default.
• W3142733986 type Work @default.
• W3142733986 sameAs 3142733986 @default.
• W3142733986 citedByCount "14" @default.
• W3142733986 countsByYear W31427339862021 @default.
• W3142733986 countsByYear W31427339862022 @default.
• W3142733986 countsByYear W31427339862023 @default.
• W3142733986 crossrefType "journal-article" @default.
• W3142733986 hasAuthorship W3142733986A5010479257 @default.
• W3142733986 hasAuthorship W3142733986A5011248078 @default.
• W3142733986 hasAuthorship W3142733986A5046225712 @default.
• W3142733986 hasAuthorship W3142733986A5050874455 @default.
• W3142733986 hasAuthorship W3142733986A5057884992 @default.
• W3142733986 hasAuthorship W3142733986A5067749008 @default.
• W3142733986 hasAuthorship W3142733986A5068980726 @default.
• W3142733986 hasAuthorship W3142733986A5082117229 @default.
• W3142733986 hasAuthorship W3142733986A5085175356 @default.
• W3142733986 hasAuthorship W3142733986A5087284408 @default.
• W3142733986 hasAuthorship W3142733986A5091378966 @default.
• W3142733986 hasConcept C119128265 @default.
• W3142733986 hasConcept C129312508 @default.
• W3142733986 hasConcept C130197536 @default.
• W3142733986 hasConcept C137390916 @default.
• W3142733986 hasConcept C153911025 @default.
• W3142733986 hasConcept C160756335 @default.
• W3142733986 hasConcept C168931907 @default.
• W3142733986 hasConcept C171250308 @default.
• W3142733986 hasConcept C185592680 @default.
• W3142733986 hasConcept C192562407 @default.
• W3142733986 hasConcept C21951064 @default.
• W3142733986 hasConcept C43617362 @default.
• W3142733986 hasConcept C552990157 @default.
• W3142733986 hasConcept C55493867 @default.
• W3142733986 hasConcept C75473681 @default.
• W3142733986 hasConcept C86803240 @default.
• W3142733986 hasConceptScore W3142733986C119128265 @default.
• W3142733986 hasConceptScore W3142733986C129312508 @default.
• W3142733986 hasConceptScore W3142733986C130197536 @default.
• W3142733986 hasConceptScore W3142733986C137390916 @default.
• W3142733986 hasConceptScore W3142733986C153911025 @default.
• W3142733986 hasConceptScore W3142733986C160756335 @default.
• W3142733986 hasConceptScore W3142733986C168931907 @default.
• W3142733986 hasConceptScore W3142733986C171250308 @default.
• W3142733986 hasConceptScore W3142733986C185592680 @default.
• W3142733986 hasConceptScore W3142733986C192562407 @default.
• W3142733986 hasConceptScore W3142733986C21951064 @default.
• W3142733986 hasConceptScore W3142733986C43617362 @default.
• W3142733986 hasConceptScore W3142733986C552990157 @default.
• W3142733986 hasConceptScore W3142733986C55493867 @default.
• W3142733986 hasConceptScore W3142733986C75473681 @default.

• next