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- W3142823606 abstract "Ethane-1-hydroxy-1,1-diphosphonate (EHDP, disodium etidronate), a compound known to block the growth and dissolution of apatite crystals in vitro and to slow bone turnover rate in experimental animals, has been given orally to 10 men with Paget's disease of bone. In nine patients the plasma alkaline phosphatase, plasma hydroxyproline, and urinary total hydroxyproline, all of which were increased above normal before treatment, fell considerably within three months of starting EHDP. In seven of these patients these measurements had decreased to normal or near normal values after periods of treatment up to seven months. The one patient who showed no significant biochemical change had diarrhoea before treatment and may have failed to absorb the compound.These changes were accompanied by a reversible increase in plasma phosphate which was most marked in the least severe cases.In four patients there was some biochemical evidence for recurrence of the Paget's disease after stopping EHDP but this did not occur in less than three months. One patient with generalized Paget's disease, who responded well to EHDP, showed no biochemical evidence of recurrence a year after treatment was stopped.Bone biopsies taken from the iliac crest at various times after stopping EHDP showed few bone cells and a patchy accumulation of osteoid in five out of six patients.Thus, disodium etidronate appears to reduce the excessive resorption and remodelling of bone that is characteristic of Paget's disease, but at the dose so far used seems also to impair the mineralization of both normal and diseased bone. The effect of smaller doses is being investigated." @default.
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- W3142823606 date "1973-04-01" @default.
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- W3142823606 title "Paget's Disease of Bone" @default.
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