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- W3142884911 abstract "目的 探讨肾综合征出血热(hemorrhagic fever with renal syndrome,HFRS)患者CD17s+T淋巴细胞的本质及其在致病过程中的作用.方法应用流式细胞仪(flow cytometry,FCM)对56份HFRS患者外周血标本进行检测,分析CD17s在HFRS淋巴细胞亚群和活化淋巴细胞中的表达及其动态变化.结果HFRS发热期和多尿期CD4+CD178+及CDs+CD178+T淋巴细胞与对照组比较明显增加,差异具有统计学意义.HFRS发热期和多尿期CD178在CD4+HLA-DR+T淋巴细胞群及CD8+HLA-DR+T淋巴细胞群表达均明显增高,与正常对照组比较,差异具有统计学意义;而发热期与多尿期之间比较,差异无统计学意义.结论HFRS的发病过程中CDi78表达于活化CD4+淋巴细胞亚群,主要表达于CD8+T细胞亚群,且病程早期和后期均有高表达.推测在发病早期细胞毒T细胞(cytotoxic T lymphocyte,CTL)通过CD178介导的细胞调亡清除病毒感染的靶细胞,在疾病末期则通过清除活化的抗原特异性T细胞,维持机体免疫自身的稳定。" @default.
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- W3142884911 date "2005-12-31" @default.
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- W3142884911 title "A clinical study on CD178 positive T lymphocyte in hemorrhagic fever with renal syndrome" @default.
- W3142884911 doi "https://doi.org/10.3760/cma.j.issn.1003-9279.2005.04.018" @default.
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