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- W3142899106 abstract "Summary. A patient with a severe bleeding tendency due toacquired von Willebrand disease (VWD) is presented.Although no underlying disorder has emerged during 6years of follow-up, an immune-mediated mechanism wasresponsible for acquired VWD in this patient as demon-strated by detection of von Willebrand factor (VWF)/anti-VWF complexes in the patient’s plasma and their removal byprotein A–sepharose beads and resumption of normalhaemostasis with correction of VWF antigen, VWF activityand VWF multimeric pattern after treatment of the patientwith high-dose gammaglobulin. Detection of anti-VWFantibodies in the patient’s plasma had a significantimpact on the choice of therapeutic intervention to controlbleeding. Keywords: acquired von Willebrand disease.Acquired VWD results from quantitative and/or qualitativedefect(s) in VWF mimicking the clinical and laboratoryfeatures of hereditary VWD (Handin et al , 1976). It has beenreported mostly in patients with lymphoproliferative dis-orders (Mannucci" @default.
- W3142899106 created "2021-04-13" @default.
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- W3142899106 date "1997-01-01" @default.
- W3142899106 modified "2023-09-27" @default.
- W3142899106 title "Acquired von Willebrand disease in a patient with angiodysplasia resulting from immune-mediated clearance of von Willebrand factor" @default.
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