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- W3142921601 abstract "AIM: To investigate biological effects of transthyretin(TTR) on the development of neovascularization under simulated diabetic retinopathy(DR) condition associated with high glucose and hypoxia. METHODS: Human retinal microvascular endothelial cells(h RECs) were cultured in normal and simulated DR environments with high glucose and hypoxia. The normal serum glucose concentration is approximately 5.5 mmol/L;thus, hyperglycemia was simulated with 25 mmol/L glucose, while hypoxia was induced using 200 μmol/L Co Cl2. The influence of TTR on h RECs and human retinal pigment epithelial cells(h RPECs) was determined by incubating the cells with 4 μmol/L TTR in normal and abnormal media. A co-culture system was then employed to evaluate the effects of h RPECs on h RECs. RESULTS: Decreased h RECs and h RPECs were observed under abnormal conditions, including high-glucose and hypoxic media. In addition, h RECs were significantly inhibited by 4 μmol/L exogenous TTR during hyperglycemic culture. During co-culture, h RPECs inhibited h RECs in both the normal and abnormal environments.CONCLUSION: h REC growth is inhibited by exogenous TTR under simulated DR environments with high-glucose and hypoxic, particularly in the medium containing 25 mmol/L glucose. h RPECs, which manufacture TTR in the eye, also represses h RECs in the same environment. TTR is predicted to inhibit the proliferation of h RECs and neovascularization." @default.
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- W3142921601 date "2016-01-01" @default.
- W3142921601 modified "2023-09-24" @default.
- W3142921601 title "Repression of retinal microvascular endothelial cells by transthyretin under simulated diabetic retinopathy conditions" @default.
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