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• W3142938554 endingPage "104188" @default.
• W3142938554 startingPage "104188" @default.
• W3142938554 abstract "Intracranial saccular aneurysms (ISA) represent 90%–95% of all intracranial aneurysm cases, characterizing abnormal pockets at arterial branch points. Ruptures lead to subarachnoid hemorrhages (SAH) and poor prognoses. We applied mass spectrometry-based peptidomics to investigate the peptidome of twelve cerebrospinal fluid (CSF) samples collected from eleven patients diagnosed with ISA. For peptide profile analyses, participants were classified into: 1) ruptured intracranial saccular aneurysms (RIA), 2) unruptured intracranial saccular aneurysms (UIA), and late-ruptured intracranial saccular aneurysms (LRIA). Altogether, a total of 2199 peptides were detected by both Mascot and Peaks software, from which 484 (22.0%) were unique peptides. All unique peptides presented conserved chains, domains, regions of protein modulation and/or post-translational modification sites related to human diseases. Gene Ontology (GO) analyses of peptide precursor proteins showed that 42% are involved in binding, 56% in cellular anatomical entities, and 39% in intercellular signaling molecules. Unique peptides identified in patients diagnosed with RIA have a larger molecular weight and a distinctive developmental process compared to UIA and LRIA (P ≤ 0.05). Continued investigations will allow the characterization of the biological and clinical significance of the peptides identified in the present study, as well as identify prototypes for peptide-based pharmacological therapies to treat ISA. Intracranial aneurysms (IAs) are arterial dilations that occur due to weakness in the media layer of the arterial wall. Due to lack of symptoms, IAs are usually found incidentally when the rupture occurs. The mechanism that causes vasospasms are not completely understood. Here, twelve cerebrospinal fluid (CSF) samples collected from eleven patients diagnosed with IAs were investigated by mass spectrometry-based peptidomics. 2199 peptides were identified by both Mascot and Peaks software, from which 484 (22.0%) were unique peptides. Even considering the relatively low number of patients enrolled in this seminal study, all unique peptides presented conserved chains, domains, regions of protein modulation and/or post-translational modification sites related to human diseases. Gene Ontology (GO) analyses of peptide precursor proteins showed that 42% are involved in binding, 56% in cellular anatomical entities, and 39% in intercellular signaling molecules. Unique peptides identified in patients diagnosed with RIA have a larger molecular weight and a distinctive developmental process compared to UIA and LRIA (P ≤ 0.05). These results suggest peptides as novel ISA markers. Continued investigations will allow the undoubted characterization of specific peptides that can be used as prototypes for peptide-based diagnostics and pharmacological therapies, to predict, prevent and/or treat ISA." @default.
• W3142938554 created "2021-04-13" @default.
• W3142938554 creator A5038522003 @default.
• W3142938554 creator A5046461222 @default.
• W3142938554 creator A5050349935 @default.
• W3142938554 creator A5066356785 @default.
• W3142938554 creator A5073609720 @default.
• W3142938554 creator A5075757387 @default.
• W3142938554 creator A5078552361 @default.
• W3142938554 creator A5091379025 @default.
• W3142938554 date "2021-05-01" @default.
• W3142938554 modified "2023-10-15" @default.
• W3142938554 title "Peptidomic profiling of cerebrospinal fluid from patients with intracranial saccular aneurysms" @default.
• W3142938554 cites W1489689270 @default.
• W3142938554 cites W1500108064 @default.
• W3142938554 cites W1510961866 @default.
• W3142938554 cites W1513849811 @default.
• W3142938554 cites W18440955 @default.
• W3142938554 cites W1874700596 @default.
• W3142938554 cites W1964679579 @default.
• W3142938554 cites W1967003637 @default.
• W3142938554 cites W1977064582 @default.
• W3142938554 cites W1985359736 @default.
• W3142938554 cites W1988208930 @default.
• W3142938554 cites W1991952373 @default.
• W3142938554 cites W1993652875 @default.
• W3142938554 cites W2002319782 @default.
• W3142938554 cites W2002697163 @default.
• W3142938554 cites W2012591661 @default.
• W3142938554 cites W2018766348 @default.
• W3142938554 cites W2019125083 @default.
• W3142938554 cites W2020106539 @default.
• W3142938554 cites W2020240585 @default.
• W3142938554 cites W2024322336 @default.
• W3142938554 cites W2025170810 @default.
• W3142938554 cites W2025203280 @default.
• W3142938554 cites W2033748252 @default.
• W3142938554 cites W2035121886 @default.
• W3142938554 cites W2037642018 @default.
• W3142938554 cites W2049516042 @default.
• W3142938554 cites W2050939799 @default.
• W3142938554 cites W2051119464 @default.
• W3142938554 cites W2056782561 @default.
• W3142938554 cites W2060752639 @default.
• W3142938554 cites W2062346425 @default.
• W3142938554 cites W2064994171 @default.
• W3142938554 cites W2068696470 @default.
• W3142938554 cites W2071468617 @default.
• W3142938554 cites W2077405632 @default.
• W3142938554 cites W2083160102 @default.
• W3142938554 cites W2083381199 @default.
• W3142938554 cites W2085760247 @default.
• W3142938554 cites W2087298783 @default.
• W3142938554 cites W2089129607 @default.
• W3142938554 cites W2109642602 @default.
• W3142938554 cites W2117039580 @default.
• W3142938554 cites W2119495025 @default.
• W3142938554 cites W2120032466 @default.
• W3142938554 cites W2120081884 @default.
• W3142938554 cites W2123591210 @default.
• W3142938554 cites W2126743932 @default.
• W3142938554 cites W2146104000 @default.
• W3142938554 cites W2166987747 @default.
• W3142938554 cites W2168925567 @default.
• W3142938554 cites W2169636187 @default.
• W3142938554 cites W2189955651 @default.
• W3142938554 cites W2233981845 @default.
• W3142938554 cites W2238347332 @default.
• W3142938554 cites W2335058758 @default.
• W3142938554 cites W2417074969 @default.
• W3142938554 cites W2442228634 @default.
• W3142938554 cites W2523849022 @default.
• W3142938554 cites W2531840407 @default.
• W3142938554 cites W2558586574 @default.
• W3142938554 cites W2599353531 @default.
• W3142938554 cites W2610506360 @default.
• W3142938554 cites W2752965739 @default.
• W3142938554 cites W2767720059 @default.
• W3142938554 cites W2789925766 @default.
• W3142938554 cites W2790707565 @default.
• W3142938554 cites W2799390081 @default.
• W3142938554 cites W2806476881 @default.
• W3142938554 cites W2889244502 @default.
• W3142938554 cites W2898440040 @default.
• W3142938554 cites W2898998061 @default.
• W3142938554 cites W2899760200 @default.
• W3142938554 cites W2917101543 @default.
• W3142938554 cites W2936512562 @default.
• W3142938554 cites W2941646620 @default.
• W3142938554 cites W2941884036 @default.
• W3142938554 cites W2945389650 @default.
• W3142938554 cites W2950742983 @default.
• W3142938554 cites W2980089649 @default.
• W3142938554 cites W2991812010 @default.
• W3142938554 cites W3006269376 @default.
• W3142938554 cites W3009081386 @default.
• W3142938554 cites W3020532770 @default.
• W3142938554 cites W3031580100 @default.

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