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- W3142987029 abstract "Objective To evaluate the toxic action on testis and epididymides of mature male KM mice by isophorone diisocyanate(IPDI) and the related mechanism.Methods One hundred and twenty 8-month-old healthy KM mice in total were intraperitoneally injected with IPDI maize oil solution at the dose of 0,50,100,200 mg/kg in a normal control group and 3 experiment groups respectively once everyday for 14 days.Each group included 30 randomly selected mice and injection dose was 12.5 ml/kg.bw for each mouse.The male mice were killed on day 15 for the measurement of the viscera coefficient of testis and epididymides,the sperm count in epididymides,the activities of enzymes of testis(ACP,AKP,LDH,SDH,NOS,Ca-Mg-ATPase,Na-K-ATPase),and concentration of related hormone in testis and blood serum(LH,FSH,T).Results There were no significant differences in body weight,epididymides weight and its viscera coefficient between 3 experiment groups and the control group(P 0.05).Compared with the control group,the weight and viscera coefficient of testis in high dosage group,the sperm counts of epididymides in medium and high dosage experiment groups were all decreased significantly(P0.05 or P0.01).There were no statistical significances in the activities of lactate dehydrogenase(LDH) and Na-K-ATPase in testis between the experiment groups and the control group(P0.05).The activities of succinate dehydrogenase(SDH) and nitric oxide synthase(NOS) of testis in high dosage group,the activities of acid phosphatase(ACP),alkaline phosphatase(AKP) and Ca-Mg-ATPase of testis in medium and high doseage groups were all decreased significantly compared with the control group(P0.05 or P0.01).Compared with the control group,the concentrations of testosterone(T) in serum of all 3 experiment groups and the concentrations of testosterone in testis of medium and high dosage groups were all significantly decreased(P0.01),while the concentrations of follicle stimulating hormone(FSH) of serum in all 3 experiment groups and the concentrations of luteinizing hormone(LH) of serum in medium and high dosage groups were all significantly increased(P0.01).Conclusion Under the conditions of this research,IPDI exposure could induced arrenotokous toxic action on testis of mature male KM mice." @default.
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- W3142987029 date "2009-01-01" @default.
- W3142987029 modified "2023-09-23" @default.
- W3142987029 title "Study on Toxic Action on Testis and Epididymides of Mature Male Mice by Isophorone Diisocyanate and Its Mechanism" @default.
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