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• W3143008758 endingPage "113237" @default.
• W3143008758 startingPage "113237" @default.
• W3143008758 abstract "Hypoxia-ischemia (HI) is a consequence of a lack of oxygen and glucose support to the developing brain, which causes several neurodevelopmental impairments. Environmental enrichment (EE) is considered an option to recover the alterations observed in rodents exposed to HI. The aim of this study was to investigate the impact of early EE on memory, hippocampal volume and brain-derived neurotrophic factor (Bbnf) and glucocorticoid receptor (Nr3c1) gene expression of mice exposed to HI. At P10, pups underwent right carotid artery permanent occlusion followed by 35 min of 8% O2 hypoxic environment. Starting at P11, animals were reared in EE or in standard cage (HI-SC or SHAM-SC) conditions until behavioral testing (P45). SHAM pups did not undergo carotid ligation and hypoxic exposure. Memory performance was assessed in the Y-maze, Novel object recognition, and Barnes maze. Animals were then sacrificed for analysis of hippocampal volume and Bdnf and Nr3c1 gene expression. We observed that animals exposed to HI performed worse in all three tests compared to SHAM animals. Furthermore, HI animals exposed to EE did not differ from SHAM animals in all tasks. Moreover, HI decreased hippocampal volume, while animals reared in early EE were not different compared to SHAM animals. Animals exposed to HI also showed upregulated hippocampal Bdnf expression compared to SHAM animals. We conclude that early EE from P11 to P45 proved to be effective in recovering memory impairments and hippocampal volume loss elicited by HI. Nevertheless, Bdnf expression was not associated with the improvements in memory performance observed in animals exposed to EE after a hypoxic-ischemic event." @default.
• W3143008758 created "2021-04-13" @default.
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• W3143008758 date "2021-06-01" @default.
• W3143008758 modified "2023-10-17" @default.
• W3143008758 title "Early environmental enrichment rescues memory impairments provoked by mild neonatal hypoxia-ischemia in adolescent mice" @default.
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• W3143008758 doi "https://doi.org/10.1016/j.bbr.2021.113237" @default.
• W3143008758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33798820" @default.
• W3143008758 hasPublicationYear "2021" @default.
• W3143008758 type Work @default.

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