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- W3143011199 abstract "高血压生产为与疾病联系的死亡经常负责的 pathophysiological 变化。overactive 高血压蛋白原酶血管收缩素系统在高血压和与高血压联系的目标机关损坏的发展起一个中央作用，是明显的。我们以前发现了新奇血管收缩素受体(AT1 ) vaccine-ATR12181 在自发地高血压的老鼠(SHR ) 稀释了高血压(BP ) 的发展人的必要高血压的模型。我们的目的是决定高 BP 的这变细是否与由高血压的状态导致的目标机关损坏的预防被联系。SHR 被在联合复杂的 peptide-tetanus-toxoid 的重复下的注射与 Freund 的助手从 AT1A 受体的 extracelluar 部分对肽(编码 ATR12181 ) 使免疫。64 个星期长期的观察被执行。重复种痘导致了 anti-ATR12181 抗体的正式就职。在观察的结束，种牛痘表明的 SHR 降低肾损害的 BP，减少的心脏的肥大和变细。在心和肾的 c-fos 和 c-jun 的 mRNA 层次在种牛痘的 SHR 被减少。因为自我抗原被使用，疫苗的安全被担心。然而，自体免疫的疾病的符号没在心和肾的节被观察。这些数据证明对 AT1 受体的细胞外的部分的域的那重复免疫能对高血压引起一个目标机关保护。对 AT1 受体的活跃免疫可以在高血压的治疗被看作有希望的新策略。" @default.
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- W3143011199 date "2006-01-01" @default.
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- W3143011199 title "Target Organ Protection from a Novel Angiotensin II Receptor （AT1） Vaccine ATR12181 in Spontaneously Hypertensive Rats" @default.
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