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- W3143042789 abstract "Objective To understand the possible role of signal transducer and activator of transcription 1(STAT1)and interferon-γ(IFN-γ)in the generation of local lesions of oral lichen planus(OLP).Methods Formalin-fixed,paraffin-embedded tissues of 10cases of normal oral epithelium and 48cases of OLP were investigated for STAT1and IFN-γproteins by using immunohistochemistry SABC method.The correlation between the expression of STAT1 and IFN-γ proteins and the clinical and pathological characteristics in OLP were statistically analyzed.Results ① STAT1and IFN-γwere over expressed compared with healthy oral mucosa(P 0.05).② The percentage of STAT1over-expression in OLP with positive IFN-γstaining was significantly higher than that in OLP with negative IFN-γstaining(χ2=5.042,P0.05).A positive correlation between the overexpression of STAT1and IFN-γwas seen in OLP(r=0.324,P0.05).③ The percentage of over-expression of STAT1in OLP with disease course less than 6months was higher than that in OLP with disease course more than 6 months(χ2=5.077,P0.05),and a positive correlation was observed between the over-expression of IFN-γand the liquefaction of base cells in local lesions of OLP(r=-0.388,P0.05).Conclusion The over-expression of STAT1and IFN-γmay participate in the generation of local pathological damnification of OLP at the early stage." @default.
- W3143042789 created "2021-04-13" @default.
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- W3143042789 date "2014-01-01" @default.
- W3143042789 modified "2023-09-23" @default.
- W3143042789 title "The Over-expression of STAT1 and IFN-γin Lesions of Human Oral Lichen Planus" @default.
- W3143042789 hasPublicationYear "2014" @default.
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