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- W3143097029 abstract "Objective To investigate the HPV subtype distribution of people who is diagnosed of CIN and to discuss the relevance between different HPV subtypes infection and their CIN lesions degree.Methods Patients who choose the combination use of liquid-based cervical cytology test and HPV-DNA genotyping for their screening between Jan.2006 and Dec.2008 in the Obstetrics and Gynecology of Peking University First Hospital.We use colposcopy and multi-point biopsy for further detection,There were 624 cases diagnosed of CIN by histopathology.To analyze and summary HPV infection conditions,HPV subtype distribution and their correlation with lesion degree,then discuss the correlation between the most common HPV subtype with cervical lesions degree in CIN patients.Results There were 624 cases of CIN patients in total,CIN1 204 cases,32.7%,HPV infection rate is 85.8%,21 subtypes were detected,the top five common subtypes were 16,58,52,33 and 31;CIN2 and CIN3 420 cases,67.3%,HPV infection rate is 90.7%,19 subtypes were detected,the top five common subtypes were 16,58,33,52 and 31.In different degrees of CIN,HPV16,52 infections have significant difference statistically (χ2,respectively 64.010,5.992,P= 0.000,0.023),the other subtypes have no significant difference (P0.05).We classified CIN into high grade and low grade lesion according to CIN1 and CIN2、3.By Logistic regression analysis,HPV 16,33,52 and 59 have a certain correlation with CIN lesion degree,the coefficient B were 1.526,0.676,-0.460,-1.139 respectively.Conclusion The most common subtypes of HPV infection in CIN patients are l6,58,52,33 and 31 types,HPVl6,33 is the main pathogenic subtype of CIN2,3." @default.
- W3143097029 created "2021-04-13" @default.
- W3143097029 creator A5058844832 @default.
- W3143097029 date "2010-01-01" @default.
- W3143097029 modified "2023-09-24" @default.
- W3143097029 title "HPV subtype distribution in CIN patients" @default.
- W3143097029 hasPublicationYear "2010" @default.
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