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- W3143137798 abstract "53molecules. (a) 53 NSGM (G1-G12) were examined for growth in monolayer and spheroid conditions (Screen 1) followed by primary versus secondary/tertiary growth (Screen 2). The dual tandem screen identified three ‘lead' NSGMs (G2.2, G11.1 and G12.2) that selectively target self-renewing colorectal CSCs. Two structural analogues of G2.2 (G1.4 & G4.1) were also chosen for studying molecular specificity of inhibition. (b) 20 NSGMs (4 active scaffold G2, G4, G11 and G12, identified in screen 1), were examined for primary spheroid growth in HCT-116 and HT-29 cell with distinct genetic backgrounds. (c) 11 NSGMs (arrows in (B)) that showed >50% inhibition in both cell lines (p<0.0005) were further tested for secondary /tertiary sphere formation to examine effect on CSC self-renewal. Only 3 NSGMs, i.e., G2.2, G11.1 and G12.2 (arrows), demonstrated significant (p <0.0005) growth inhibition. Data is represented as percent of control." @default.
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- W3143137798 date "2014-01-01" @default.
- W3143137798 modified "2023-09-27" @default.
- W3143137798 title "397 MicoRNA's in Regulation of Colon Cancer Stem Cells" @default.
- W3143137798 hasPublicationYear "2014" @default.
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