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- W3143143771 abstract "Objectives To study the association of narcolepsy with HLA class Ⅱ alleles in Chinese narcoleptic patients. Methods 31 patients with narcolepsy underwent brain computed tomography (CT) scan and magnetic resonance imaging (MRI) testing. All patients received a MSLT test following a routine night′s sleep, and serological HLA typing for HLA DR 2. 21 patients received PCR-SSP HLA DR and DQ typing. Results All patients had sleepiness and cataplexy. There was no evidence for other functional or structural diseases. Sleep paralysis was elicited in 45%; hypnagogic hallucinations, in 61%. Mean sleep latency on MSLT was 2.1 min±1.3 min; sleep-onset rapid eye movement (SOREM) occurred during 2/5 naps in 30 of 31 patients. The average number and latency of SOREM episodes were 4.2±1.0 episodes and 4.0 min±1.8 min, respectively. All patients but one were HLA DR 2 positive and 86% were HLADRB 1*1501-HLADQB 1*0602 positive. Conclusions HLA DR 2 and HLADQw6 are markers for narcolepsy-cataplexy in Chinese." @default.
- W3143143771 created "2021-04-13" @default.
- W3143143771 creator A5053620980 @default.
- W3143143771 date "2003-01-01" @default.
- W3143143771 modified "2023-09-24" @default.
- W3143143771 title "HLA-DRB and- DQB allele contribution to narcolepsy susceptibility in Chinese patients with narcolepsy" @default.
- W3143143771 hasPublicationYear "2003" @default.
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