Matches in SemOpenAlex for { <https://semopenalex.org/work/W3143146913> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W3143146913 abstract "The gene iscS-2 from extremophile Acidithiobacillus ferrooxidans may play a crucial role in nitrogenase maturation. To investigate the protein encoded by this gene, a reliable integral three-dimensional molecular structure was built. The obtained structure was further used to search binding sites, carry out the flexible docking with cofactor pyridoxal 5′-phosphate(PLP) and substrate cysteine, and identify its key residues. The docking results of PLP reveal that the residues of Lys203, His100, Thr73, Ser200, His202, Asp177 and Gln180 have large interaction energies and/or hydrogen bonds fixation with PLP. The docking results of cysteine show that the amino group in cysteine is very near His100, Lys203 and PLP, and the interaction energies for cysteine with them are very big. These identified residues are in line with the experimental facts of NifS from other sources. Moreover, the four residues of Asn152, Val179, Ala102 and Met148 in the PLP docking and the two residues of Lys208 and Ala102 in the cysteine docking also have large interaction energies, which are fitly conserved in NifS from all kinds of sources but have not been identified before. According to these results, this gene encodes NifS protein, and the substrate cysteine can be effectively recruited into the active site. Furthermore, all of the above detected key residues are directly responsible for the binding and/or catalysis of PLP and cysteine." @default.
- W3143146913 created "2021-04-13" @default.
- W3143146913 creator A5084634014 @default.
- W3143146913 date "2008-01-01" @default.
- W3143146913 modified "2023-09-26" @default.
- W3143146913 title "Full structure building and docking of NifS from extremophile Acidithiobacillus ferrooxidans" @default.
- W3143146913 hasPublicationYear "2008" @default.
- W3143146913 type Work @default.
- W3143146913 sameAs 3143146913 @default.
- W3143146913 citedByCount "0" @default.
- W3143146913 crossrefType "journal-article" @default.
- W3143146913 hasAuthorship W3143146913A5084634014 @default.
- W3143146913 hasConcept C107824862 @default.
- W3143146913 hasConcept C159110408 @default.
- W3143146913 hasConcept C181199279 @default.
- W3143146913 hasConcept C185592680 @default.
- W3143146913 hasConcept C197957613 @default.
- W3143146913 hasConcept C205458427 @default.
- W3143146913 hasConcept C2776834122 @default.
- W3143146913 hasConcept C2779201268 @default.
- W3143146913 hasConcept C27911776 @default.
- W3143146913 hasConcept C41183919 @default.
- W3143146913 hasConcept C41685203 @default.
- W3143146913 hasConcept C47701112 @default.
- W3143146913 hasConcept C55493867 @default.
- W3143146913 hasConcept C71240020 @default.
- W3143146913 hasConcept C71924100 @default.
- W3143146913 hasConceptScore W3143146913C107824862 @default.
- W3143146913 hasConceptScore W3143146913C159110408 @default.
- W3143146913 hasConceptScore W3143146913C181199279 @default.
- W3143146913 hasConceptScore W3143146913C185592680 @default.
- W3143146913 hasConceptScore W3143146913C197957613 @default.
- W3143146913 hasConceptScore W3143146913C205458427 @default.
- W3143146913 hasConceptScore W3143146913C2776834122 @default.
- W3143146913 hasConceptScore W3143146913C2779201268 @default.
- W3143146913 hasConceptScore W3143146913C27911776 @default.
- W3143146913 hasConceptScore W3143146913C41183919 @default.
- W3143146913 hasConceptScore W3143146913C41685203 @default.
- W3143146913 hasConceptScore W3143146913C47701112 @default.
- W3143146913 hasConceptScore W3143146913C55493867 @default.
- W3143146913 hasConceptScore W3143146913C71240020 @default.
- W3143146913 hasConceptScore W3143146913C71924100 @default.
- W3143146913 hasLocation W31431469131 @default.
- W3143146913 hasOpenAccess W3143146913 @default.
- W3143146913 hasPrimaryLocation W31431469131 @default.
- W3143146913 hasRelatedWork W1969990260 @default.
- W3143146913 hasRelatedWork W1975998832 @default.
- W3143146913 hasRelatedWork W1979259791 @default.
- W3143146913 hasRelatedWork W1993234422 @default.
- W3143146913 hasRelatedWork W2011505383 @default.
- W3143146913 hasRelatedWork W2011602281 @default.
- W3143146913 hasRelatedWork W2020733788 @default.
- W3143146913 hasRelatedWork W2041079052 @default.
- W3143146913 hasRelatedWork W2054274383 @default.
- W3143146913 hasRelatedWork W2079366032 @default.
- W3143146913 hasRelatedWork W2125614187 @default.
- W3143146913 hasRelatedWork W2128927484 @default.
- W3143146913 hasRelatedWork W2143669174 @default.
- W3143146913 hasRelatedWork W2155183427 @default.
- W3143146913 hasRelatedWork W2187540159 @default.
- W3143146913 hasRelatedWork W2293350757 @default.
- W3143146913 hasRelatedWork W2333025345 @default.
- W3143146913 hasRelatedWork W2443579361 @default.
- W3143146913 hasRelatedWork W2470459900 @default.
- W3143146913 hasRelatedWork W3017419889 @default.
- W3143146913 isParatext "false" @default.
- W3143146913 isRetracted "false" @default.
- W3143146913 magId "3143146913" @default.
- W3143146913 workType "article" @default.