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- W3143151569 abstract "Serine-rich splicing factor 3 (SRSF3) was recently reported as being necessary to preserve RNA stability via an mTOR mechanism in a cardiac mouse model in adulthood. Here, we demonstrate the link between Srsf3 and mitochondrial integrity in an embryonic cardiomyocyte-specific Srsf3 conditional knockout (cKO) mouse model. Fifteen-day-old Srsf3 cKO mice showed dramatically reduced (below 50%) survival and reduced the left ventricular systolic performance, and histological analysis of these hearts revealed a significant increase in cardiomyocyte size, confirming the severe remodeling induced by Srsf3 deletion. RNA-seq analysis of the hearts of 5-day-old Srsf3 cKO mice revealed early changes in expression levels and alternative splicing of several transcripts related to mitochondrial integrity and oxidative phosphorylation. Likewise, the levels of several protein complexes of the electron transport chain decreased, and mitochondrial complex I-driven respiration of permeabilized cardiac muscle fibers from the left ventricle was impaired. Furthermore, transmission electron microscopy analysis showed disordered mitochondrial length and cristae structure. Together with its indispensable role in the physiological maintenance of mouse hearts, these results highlight the previously unrecognized function of Srsf3 in regulating the mitochondrial integrity." @default.
- W3143151569 created "2021-04-13" @default.
- W3143151569 creator A5014251187 @default.
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- W3143151569 creator A5043986649 @default.
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- W3143151569 creator A5051422729 @default.
- W3143151569 creator A5068905113 @default.
- W3143151569 creator A5075735538 @default.
- W3143151569 creator A5082027663 @default.
- W3143151569 date "2021-04-05" @default.
- W3143151569 modified "2023-10-17" @default.
- W3143151569 title "Cardiomyocyte‐specific Srsf3 deletion reveals a mitochondrial regulatory role" @default.
- W3143151569 cites W1551776366 @default.
- W3143151569 cites W1571391428 @default.
- W3143151569 cites W1846021790 @default.
- W3143151569 cites W1856059666 @default.
- W3143151569 cites W190096672 @default.
- W3143151569 cites W1966353724 @default.
- W3143151569 cites W1968550540 @default.
- W3143151569 cites W1969707555 @default.
- W3143151569 cites W1971599917 @default.
- W3143151569 cites W1986403448 @default.
- W3143151569 cites W1990171977 @default.
- W3143151569 cites W1993477468 @default.
- W3143151569 cites W1997919268 @default.
- W3143151569 cites W2005467167 @default.
- W3143151569 cites W2006368030 @default.
- W3143151569 cites W2008929866 @default.
- W3143151569 cites W2010012966 @default.
- W3143151569 cites W2013006994 @default.
- W3143151569 cites W2017213538 @default.
- W3143151569 cites W2036933116 @default.
- W3143151569 cites W2038912141 @default.
- W3143151569 cites W2044935906 @default.
- W3143151569 cites W2045949302 @default.
- W3143151569 cites W2046772778 @default.
- W3143151569 cites W2048255587 @default.
- W3143151569 cites W2059060273 @default.
- W3143151569 cites W2061810465 @default.
- W3143151569 cites W2066123764 @default.
- W3143151569 cites W2066828912 @default.
- W3143151569 cites W2072172413 @default.
- W3143151569 cites W2082690232 @default.
- W3143151569 cites W2085648653 @default.
- W3143151569 cites W2088166975 @default.
- W3143151569 cites W2090333731 @default.
- W3143151569 cites W2091592969 @default.
- W3143151569 cites W2098297062 @default.
- W3143151569 cites W2098516117 @default.
- W3143151569 cites W2098590189 @default.
- W3143151569 cites W2101117598 @default.
- W3143151569 cites W2104657885 @default.
- W3143151569 cites W2104810015 @default.
- W3143151569 cites W2107228426 @default.
- W3143151569 cites W2119201749 @default.
- W3143151569 cites W2119204091 @default.
- W3143151569 cites W2120064241 @default.
- W3143151569 cites W2126201693 @default.
- W3143151569 cites W2131271579 @default.
- W3143151569 cites W2133481284 @default.
- W3143151569 cites W2134208169 @default.
- W3143151569 cites W2139777426 @default.
- W3143151569 cites W2143588920 @default.
- W3143151569 cites W2145825942 @default.
- W3143151569 cites W2151698573 @default.
- W3143151569 cites W2153819921 @default.
- W3143151569 cites W2154201149 @default.
- W3143151569 cites W2154430605 @default.
- W3143151569 cites W2169456326 @default.
- W3143151569 cites W2170809709 @default.
- W3143151569 cites W2171405631 @default.
- W3143151569 cites W2188647161 @default.
- W3143151569 cites W2189596073 @default.
- W3143151569 cites W2225699583 @default.
- W3143151569 cites W2228682541 @default.
- W3143151569 cites W2267116535 @default.
- W3143151569 cites W2323326409 @default.
- W3143151569 cites W2399414035 @default.
- W3143151569 cites W2465744647 @default.
- W3143151569 cites W2469678401 @default.
- W3143151569 cites W2492521149 @default.
- W3143151569 cites W2535544484 @default.
- W3143151569 cites W2539683056 @default.
- W3143151569 cites W2565443325 @default.
- W3143151569 cites W2584485311 @default.
- W3143151569 cites W2588962689 @default.
- W3143151569 cites W2592672373 @default.
- W3143151569 cites W2725540830 @default.
- W3143151569 cites W2736292045 @default.
- W3143151569 cites W2737293726 @default.
- W3143151569 cites W2751663599 @default.
- W3143151569 cites W2765403479 @default.
- W3143151569 cites W2765707159 @default.
- W3143151569 cites W2767030556 @default.
- W3143151569 cites W2772206037 @default.
- W3143151569 cites W2788114927 @default.
- W3143151569 cites W2789597829 @default.
- W3143151569 cites W2810747712 @default.