Matches in SemOpenAlex for { <https://semopenalex.org/work/W3143183721> ?p ?o ?g. }
- W3143183721 endingPage "13944" @default.
- W3143183721 startingPage "13937" @default.
- W3143183721 abstract "Protein complexes are defined by the three-dimensional structure of participating binding partners. Knowledge about these structures can facilitate the design of peptidomimetics which have been applied for example, as inhibitors of protein–protein interactions (PPIs). Even though β-sheets participate widely in PPIs, they have only rarely served as the basis for peptidomimetic PPI inhibitors, in particular when addressing intracellular targets. Here, we present the structure-based design of β-sheet mimetics targeting the intracellular protein β-catenin, a central component of the Wnt signaling pathway. Based on a protein binding partner of β-catenin, a macrocyclic peptide was designed and its crystal structure in complex with β-catenin obtained. Using this structure, we designed a library of bicyclic β-sheet mimetics employing a late-stage diversification strategy. Several mimetics were identified that compete with transcription factor binding to β-catenin and inhibit Wnt signaling in cells. The presented design strategy can support the development of inhibitors for other β-sheet-mediated PPIs." @default.
- W3143183721 created "2021-04-13" @default.
- W3143183721 creator A5001264532 @default.
- W3143183721 creator A5006596331 @default.
- W3143183721 creator A5022910501 @default.
- W3143183721 creator A5039514008 @default.
- W3143183721 creator A5044544379 @default.
- W3143183721 creator A5052633808 @default.
- W3143183721 creator A5055550723 @default.
- W3143183721 creator A5061448926 @default.
- W3143183721 creator A5068304950 @default.
- W3143183721 creator A5070184458 @default.
- W3143183721 creator A5075772816 @default.
- W3143183721 creator A5077993663 @default.
- W3143183721 creator A5088360983 @default.
- W3143183721 date "2021-05-05" @default.
- W3143183721 modified "2023-10-18" @default.
- W3143183721 title "Bicyclic β‐Sheet Mimetics that Target the Transcriptional Coactivator β‐Catenin and Inhibit Wnt Signaling" @default.
- W3143183721 cites W1535608802 @default.
- W3143183721 cites W1576533924 @default.
- W3143183721 cites W1588334150 @default.
- W3143183721 cites W1904120886 @default.
- W3143183721 cites W1969717239 @default.
- W3143183721 cites W1978927502 @default.
- W3143183721 cites W1981300064 @default.
- W3143183721 cites W1982782947 @default.
- W3143183721 cites W2004966040 @default.
- W3143183721 cites W2006013753 @default.
- W3143183721 cites W2006419043 @default.
- W3143183721 cites W2009405916 @default.
- W3143183721 cites W2014764992 @default.
- W3143183721 cites W2018138266 @default.
- W3143183721 cites W2018833204 @default.
- W3143183721 cites W2025938842 @default.
- W3143183721 cites W2042063184 @default.
- W3143183721 cites W2048639339 @default.
- W3143183721 cites W2056283033 @default.
- W3143183721 cites W2067780461 @default.
- W3143183721 cites W2070499759 @default.
- W3143183721 cites W2070506154 @default.
- W3143183721 cites W2076083257 @default.
- W3143183721 cites W2078468493 @default.
- W3143183721 cites W2081924792 @default.
- W3143183721 cites W2087574732 @default.
- W3143183721 cites W2100627513 @default.
- W3143183721 cites W2105236041 @default.
- W3143183721 cites W2109902423 @default.
- W3143183721 cites W2110957294 @default.
- W3143183721 cites W2116315632 @default.
- W3143183721 cites W2117582851 @default.
- W3143183721 cites W2118331478 @default.
- W3143183721 cites W2129826523 @default.
- W3143183721 cites W2145501898 @default.
- W3143183721 cites W2146167376 @default.
- W3143183721 cites W2149979517 @default.
- W3143183721 cites W2165371573 @default.
- W3143183721 cites W2165956359 @default.
- W3143183721 cites W2292174786 @default.
- W3143183721 cites W2315076298 @default.
- W3143183721 cites W2322286039 @default.
- W3143183721 cites W2329592726 @default.
- W3143183721 cites W2331643317 @default.
- W3143183721 cites W2398779002 @default.
- W3143183721 cites W2419350902 @default.
- W3143183721 cites W2557927788 @default.
- W3143183721 cites W2569303361 @default.
- W3143183721 cites W2586869611 @default.
- W3143183721 cites W2738812265 @default.
- W3143183721 cites W2741166200 @default.
- W3143183721 cites W2802911639 @default.
- W3143183721 cites W2811064737 @default.
- W3143183721 cites W2885872902 @default.
- W3143183721 cites W2889351910 @default.
- W3143183721 cites W2896054460 @default.
- W3143183721 cites W2897937537 @default.
- W3143183721 cites W2921678825 @default.
- W3143183721 cites W2942638985 @default.
- W3143183721 cites W2949900119 @default.
- W3143183721 cites W2978104523 @default.
- W3143183721 cites W2983590992 @default.
- W3143183721 cites W2997811773 @default.
- W3143183721 cites W3005336369 @default.
- W3143183721 cites W3015495445 @default.
- W3143183721 cites W3016053129 @default.
- W3143183721 cites W3096898590 @default.
- W3143183721 cites W4242505855 @default.
- W3143183721 cites W4247435318 @default.
- W3143183721 cites W4248205391 @default.
- W3143183721 cites W4254026498 @default.
- W3143183721 doi "https://doi.org/10.1002/anie.202102082" @default.
- W3143183721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8252567" @default.
- W3143183721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33783110" @default.
- W3143183721 hasPublicationYear "2021" @default.
- W3143183721 type Work @default.
- W3143183721 sameAs 3143183721 @default.
- W3143183721 citedByCount "27" @default.
- W3143183721 countsByYear W31431837212021 @default.
- W3143183721 countsByYear W31431837212022 @default.