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- W3143247066 abstract "Wnt/β-catenin signaling, also called canonical Wnt signaling, plays vital roles in various biological processes including early embryonic development, adult tissue homeostasis, stemness maintenance, and tumorigenesis. Canonical Wnt signaling uses β-catenin as the hub mediator to conduct signals. Cytosolic β-catenin will accumulate and translocate into nucleus upon Wnt stimulation and bind TCF/LEF transcriptional factors to trigger Wnt target gene transcription. This β-catenin/TCF complex will recruit diverse cofactors and couple chromatin remodeling events to fine-tune gene transcription. In this review, we summarize the recent important findings on the transcriptional regulations of Wnt target genes, to illustrate the basic transcriptional switch upon Wnt activation, the covalent epigenetic events and their biological significance." @default.
- W3143247066 created "2021-04-13" @default.
- W3143247066 creator A5004597523 @default.
- W3143247066 date "2014-01-01" @default.
- W3143247066 modified "2023-09-23" @default.
- W3143247066 title "Regulation of target gene transcription by Wnt/β-catenin signaling" @default.
- W3143247066 hasPublicationYear "2014" @default.
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