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- W3143259372 abstract "现在的学习的目的是调查复合的N-的保护的效果[2-( 4-hydroxy-phenyl ) -ethyl]-2-(2,5-dimethoxy-phenyl)-3-(3-methoxy-4-hydroxy-phenyl)-acrylamide (复合 FLZ )，自然 squamosamide 的新奇合成类似物，在 A 上，beta_( 25-35 )在人的成神经细胞瘤 SH-SY5Y cells.Methods 导致了毒性和它的活跃机制: SH-SY5Y 房间为 30 min 与复合 FLZ 的各种各样的集中被预先孵化然后与beta_( 25_35 )( 25 umol/L )栽培让 48 h 导致 neurotoxicity.Cell 生存能力，lactate 脱氢酶( LDH )版本，和谷胱甘肽( GSH )水平被生物化学的分析决定。细胞 apoptotic 比率和细胞内部的反应的氧种类(ROS ) 铺平被流动血细胞计数分析测量。apoptosis 蛋白质(Bcl-2 和 Bax ) 和细胞色素 c 版本的表示是由西方的污点 method.Results 的 assayed : 有 FLZ (1 和 10 亩 mol/L ) 的 SH-SY5Y 细胞的预告的处理显著地增加了细胞生存能力并且减少 LDH 版本和词法损害。另外， FLZ 稀释了导致的 A beta_( 25_35 ) apoptotic 细胞比率，调整了 apoptosis 蛋白质( Bcl-2 和 Bax )表示，并且减少从 mitochondria.FLZ 的细胞色素 c 版本显著地也禁止了 ROS 的产生和beta_( 25_35 )在 SH-SY5Y cells.Conclusion 导致的 GSH 的弄空: FLZ 对beta_( 25_35 )有保护的行动在 SH-SY5Y 细胞的 -in-duced 毒性，它可能通过它的抗氧化剂性质被调停。" @default.
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- W3143259372 date "2008-01-01" @default.
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- W3143259372 title "Novel squamosamide derivative （compound FLZ） attenuates Aβ25-35^- induced toxicity in SH-SY5Y cells" @default.
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