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- W3143289462 abstract "Objective To analyze the clinical charactersistic of boys with lupus nephritis(LN).Method Retrospective analysis was used to analyze the clinical data,renal pathological data and follow-up survey data of 24 boys with LN.Results total of 24 boys suffered from LN at the average age of 11.2±1.9 years old(ranging from 6.0 to 14 years old).The course of disease before diagnosis was 9.3±24.8months(ranging from 1 to 120 months);4 cases of them were misdiagnosed for a long time.Among them,kidney damage was the first manifestation in ten cases(41.7%),and 2 cases(8.3%) displayed only LN;23 cases(95.8%) were accompanied by proteinuria,and 24 hours uria protein ranged from 0.872 to 16.98g;5 of 23 cases(20.8%) were accompanied by kidney function damage.For clinical types,nephrotic syndrome was the main one(45.8%),and the second one was isolated proteinuria and hematuria(20.8%).Renal needle biopsies were performed in 19 cases.Class ⅣLN(57 9 %) was the most frequent pathological findings,and the second was Class Ⅴ(15.8%).In immunofluorescence detection,much aggradation of IgG and C3 was found;and A full-house pattern was found in 68.4% of biopsies.All patients accepted the therapy of adrenal cortical hormone and immunodepressive.Sixteen cases obtained clinical remission after average 3.4 months,and the remission rate was 66.7%.Six cases(25%) relapsed during follow-up survey,and two cases suffered from renal inadequacy(one was performed kidney transplantation).Conclusion The main clinical manifestation is nephrotic syndrome in the group,and the main pathologic type is Class Ⅳ.Lower morbidity and atypical clinical symptom induced misdiagnosis and missed diagnosis For this reason,the key of improving the prognosis of LN is early diagnosis,therapy,and regular follow-up survey." @default.
- W3143289462 created "2021-04-13" @default.
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- W3143289462 date "2009-01-01" @default.
- W3143289462 modified "2023-09-26" @default.
- W3143289462 title "Clinical analysis of 24 boys with lupus nephritis" @default.
- W3143289462 hasPublicationYear "2009" @default.
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