Matches in SemOpenAlex for { <https://semopenalex.org/work/W3143295481> ?p ?o ?g. }
- W3143295481 endingPage "1113" @default.
- W3143295481 startingPage "1103" @default.
- W3143295481 abstract "Toxin-antitoxin (TA) modules are small operons in bacteria and archaea that encode a metabolic inhibitor (toxin) and a matching regulatory protein (antitoxin). While their biochemical activities are often well defined, their biological functions remain unclear. In Type II TA modules, the most common class, both toxin and antitoxin are proteins, and the antitoxin inhibits the biochemical activity of the toxin via complex formation with the toxin. The different TA modules vary significantly regarding structure and biochemical activity. Both regulation of protein activity by the antitoxin and regulation of transcription can be highly complex and sometimes show striking parallels between otherwise unrelated TA modules. Interplay between the multiple levels of regulation in the broader context of the cell as a whole is most likely required for optimum fine-tuning of these systems. Thus, TA modules can go through great lengths to prevent activation and to reverse accidental activation, in agreement with recent in vivo data. These complex mechanisms seem at odds with the lack of a clear biological function." @default.
- W3143295481 created "2021-04-13" @default.
- W3143295481 creator A5038576604 @default.
- W3143295481 creator A5042854852 @default.
- W3143295481 creator A5052942121 @default.
- W3143295481 date "2021-04-07" @default.
- W3143295481 modified "2023-10-17" @default.
- W3143295481 title "Prokaryote toxin–antitoxin modules: Complex regulation of an unclear function" @default.
- W3143295481 cites W1565204025 @default.
- W3143295481 cites W1820567505 @default.
- W3143295481 cites W1963544294 @default.
- W3143295481 cites W1963873781 @default.
- W3143295481 cites W1964951600 @default.
- W3143295481 cites W1976507253 @default.
- W3143295481 cites W1985347638 @default.
- W3143295481 cites W1986262202 @default.
- W3143295481 cites W1989741928 @default.
- W3143295481 cites W1989869773 @default.
- W3143295481 cites W1996140776 @default.
- W3143295481 cites W1996804832 @default.
- W3143295481 cites W2015318086 @default.
- W3143295481 cites W2021197152 @default.
- W3143295481 cites W2022778579 @default.
- W3143295481 cites W2031205830 @default.
- W3143295481 cites W2042358635 @default.
- W3143295481 cites W2057508736 @default.
- W3143295481 cites W2062119690 @default.
- W3143295481 cites W2065335843 @default.
- W3143295481 cites W2069506825 @default.
- W3143295481 cites W2070663321 @default.
- W3143295481 cites W2075518131 @default.
- W3143295481 cites W2076073652 @default.
- W3143295481 cites W2076809355 @default.
- W3143295481 cites W2090188358 @default.
- W3143295481 cites W2092255525 @default.
- W3143295481 cites W2095012297 @default.
- W3143295481 cites W2100564823 @default.
- W3143295481 cites W2114899090 @default.
- W3143295481 cites W2122386566 @default.
- W3143295481 cites W2139302831 @default.
- W3143295481 cites W2139452383 @default.
- W3143295481 cites W2141365940 @default.
- W3143295481 cites W2254985727 @default.
- W3143295481 cites W2276745282 @default.
- W3143295481 cites W2298249827 @default.
- W3143295481 cites W2298962272 @default.
- W3143295481 cites W2312343991 @default.
- W3143295481 cites W2345986058 @default.
- W3143295481 cites W2417855243 @default.
- W3143295481 cites W2510878822 @default.
- W3143295481 cites W2560566503 @default.
- W3143295481 cites W2589526524 @default.
- W3143295481 cites W2592005830 @default.
- W3143295481 cites W2592958345 @default.
- W3143295481 cites W2600605767 @default.
- W3143295481 cites W2604858366 @default.
- W3143295481 cites W2618289559 @default.
- W3143295481 cites W2790477661 @default.
- W3143295481 cites W2791806213 @default.
- W3143295481 cites W2792362584 @default.
- W3143295481 cites W2803653111 @default.
- W3143295481 cites W2896196549 @default.
- W3143295481 cites W2915040676 @default.
- W3143295481 cites W2915535827 @default.
- W3143295481 cites W2915763151 @default.
- W3143295481 cites W2916004231 @default.
- W3143295481 cites W2929355811 @default.
- W3143295481 cites W2937019613 @default.
- W3143295481 cites W2969904097 @default.
- W3143295481 cites W2971689903 @default.
- W3143295481 cites W2995737269 @default.
- W3143295481 cites W3019098313 @default.
- W3143295481 cites W3035525526 @default.
- W3143295481 cites W3081456923 @default.
- W3143295481 cites W3090629653 @default.
- W3143295481 cites W3092608619 @default.
- W3143295481 cites W3094114287 @default.
- W3143295481 cites W3112285777 @default.
- W3143295481 doi "https://doi.org/10.1002/pro.4071" @default.
- W3143295481 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8138530" @default.
- W3143295481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33786944" @default.
- W3143295481 hasPublicationYear "2021" @default.
- W3143295481 type Work @default.
- W3143295481 sameAs 3143295481 @default.
- W3143295481 citedByCount "16" @default.
- W3143295481 countsByYear W31432954812021 @default.
- W3143295481 countsByYear W31432954812022 @default.
- W3143295481 countsByYear W31432954812023 @default.
- W3143295481 crossrefType "journal-article" @default.
- W3143295481 hasAuthorship W3143295481A5038576604 @default.
- W3143295481 hasAuthorship W3143295481A5042854852 @default.
- W3143295481 hasAuthorship W3143295481A5052942121 @default.
- W3143295481 hasBestOaLocation W31432954811 @default.
- W3143295481 hasConcept C104317684 @default.
- W3143295481 hasConcept C138885662 @default.
- W3143295481 hasConcept C179926584 @default.
- W3143295481 hasConcept C203075996 @default.
- W3143295481 hasConcept C2777367657 @default.