FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3143335768> ?p ?o ?g. }

• W3143335768 abstract "CD4+ memory T cells are an important component of the tumor microenvironment (TME) and affect tumor occurrence and progression. Nevertheless, there has been no systematic analysis of the effect of CD4+ memory T cells in gastric cancer (GC).Three datasets obtained from microarray and the corresponding clinical data of GC patients were retrieved and downloaded from the Gene Expression Omnibus (GEO) database. We uploaded the normalize gene expression data with standard annotation to the CIBERSORT web portal for evaluating the proportion of immune cells in the GC samples. The WGCNA was performed to identify the modules the CD4+ memory T cell related module (CD4+ MTRM) which was most significantly associated with CD4+ memory T cell. Univariate Cox analysis was used to screen prognostic CD4+ memory T cell-related genes (CD4+ MTRGs) in CD4+ MTRM. LASSO analysis and multivariate Cox analysis were then performed to construct a prognostic gene signature whose effect was evaluated by Kaplan-Meier curves and receiver operating characteristic (ROC), Harrell's concordance index (C-index), and decision curve analyses (DCA). A prognostic nomogram was finally established based on the CD4+ MTRGs.We observed that a high abundance of CD4+ memory T cells was associated with better survival in GC patients. CD4+ MTRM was used to stratify GC patients into three clusters by unsupervised clustering analysis and ten CD4+ MTRGs were identified. Overall survival, five immune checkpoint genes and 17 types of immunocytes were observed to be significantly different among the three clusters. A ten-CD4+ MTRG signature was constructed to predict GC patient prognosis. The ten-CD4+ MTRG signature could divide GC patients into high- and low-risk groups with distinct OS rates. Multivariate Cox analysis suggested that the ten-CD4+ MTRG signature was an independent risk factor in GC. A nomogram incorporating this signature and clinical variables was established, and the C-index was 0.73 (95% CI: 0.697-0.763). Calibration curves and DCA presented high credibility for the OS nomogram.We identified three molecule subtypes, ten CD4+ MTRGs, and generated a prognostic nomogram that reliably predicts OS in GC. These findings have implications for precise prognosis prediction and individualized targeted therapy." @default.
• W3143335768 created "2021-04-13" @default.
• W3143335768 creator A5004658590 @default.
• W3143335768 creator A5020852276 @default.
• W3143335768 creator A5026243019 @default.
• W3143335768 creator A5076511291 @default.
• W3143335768 creator A5082902092 @default.
• W3143335768 creator A5086736722 @default.
• W3143335768 date "2021-03-17" @default.
• W3143335768 modified "2023-10-12" @default.
• W3143335768 title "Molecular Subtypes and CD4+ Memory T Cell-Based Signature Associated With Clinical Outcomes in Gastric Cancer" @default.
• W3143335768 cites W1921840267 @default.
• W3143335768 cites W1966107523 @default.
• W3143335768 cites W1974811080 @default.
• W3143335768 cites W1975352805 @default.
• W3143335768 cites W1985987855 @default.
• W3143335768 cites W1997273043 @default.
• W3143335768 cites W2008529945 @default.
• W3143335768 cites W2020406481 @default.
• W3143335768 cites W2026986976 @default.
• W3143335768 cites W2033278321 @default.
• W3143335768 cites W2035618305 @default.
• W3143335768 cites W2037972262 @default.
• W3143335768 cites W2061161574 @default.
• W3143335768 cites W2078802873 @default.
• W3143335768 cites W2085125246 @default.
• W3143335768 cites W2097360283 @default.
• W3143335768 cites W2098983864 @default.
• W3143335768 cites W2101327682 @default.
• W3143335768 cites W2110252240 @default.
• W3143335768 cites W2112276624 @default.
• W3143335768 cites W2113393435 @default.
• W3143335768 cites W2115462905 @default.
• W3143335768 cites W2118278569 @default.
• W3143335768 cites W2122722718 @default.
• W3143335768 cites W2137074525 @default.
• W3143335768 cites W2144182296 @default.
• W3143335768 cites W2146512944 @default.
• W3143335768 cites W2153505392 @default.
• W3143335768 cites W2166662937 @default.
• W3143335768 cites W2256704142 @default.
• W3143335768 cites W2272984102 @default.
• W3143335768 cites W2291824721 @default.
• W3143335768 cites W2298468092 @default.
• W3143335768 cites W2417439103 @default.
• W3143335768 cites W2519986995 @default.
• W3143335768 cites W2523410448 @default.
• W3143335768 cites W2572174216 @default.
• W3143335768 cites W2610509384 @default.
• W3143335768 cites W2619520579 @default.
• W3143335768 cites W2733991343 @default.
• W3143335768 cites W2737785069 @default.
• W3143335768 cites W2791613202 @default.
• W3143335768 cites W2794041272 @default.
• W3143335768 cites W2809852321 @default.
• W3143335768 cites W2906772198 @default.
• W3143335768 cites W2911971896 @default.
• W3143335768 cites W2920600229 @default.
• W3143335768 cites W2928665623 @default.
• W3143335768 cites W2963145050 @default.
• W3143335768 cites W2973430890 @default.
• W3143335768 cites W2982414086 @default.
• W3143335768 cites W2982480789 @default.
• W3143335768 cites W3013784125 @default.
• W3143335768 cites W3016736315 @default.
• W3143335768 cites W3023594444 @default.
• W3143335768 cites W4210990885 @default.
• W3143335768 cites W4294541781 @default.
• W3143335768 doi "https://doi.org/10.3389/fonc.2020.626912" @default.
• W3143335768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8011500" @default.
• W3143335768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33816214" @default.
• W3143335768 hasPublicationYear "2021" @default.
• W3143335768 type Work @default.
• W3143335768 sameAs 3143335768 @default.
• W3143335768 citedByCount "15" @default.
• W3143335768 countsByYear W31433357682022 @default.
• W3143335768 countsByYear W31433357682023 @default.
• W3143335768 crossrefType "journal-article" @default.
• W3143335768 hasAuthorship W3143335768A5004658590 @default.
• W3143335768 hasAuthorship W3143335768A5020852276 @default.
• W3143335768 hasAuthorship W3143335768A5026243019 @default.
• W3143335768 hasAuthorship W3143335768A5076511291 @default.
• W3143335768 hasAuthorship W3143335768A5082902092 @default.
• W3143335768 hasAuthorship W3143335768A5086736722 @default.
• W3143335768 hasBestOaLocation W31433357681 @default.
• W3143335768 hasConcept C119857082 @default.
• W3143335768 hasConcept C126322002 @default.
• W3143335768 hasConcept C136764020 @default.
• W3143335768 hasConcept C143998085 @default.
• W3143335768 hasConcept C161584116 @default.
• W3143335768 hasConcept C199163554 @default.
• W3143335768 hasConcept C34626388 @default.
• W3143335768 hasConcept C37616216 @default.
• W3143335768 hasConcept C41008148 @default.
• W3143335768 hasConcept C50382708 @default.
• W3143335768 hasConcept C58471807 @default.
• W3143335768 hasConcept C71924100 @default.
• W3143335768 hasConcept C86803240 @default.
• W3143335768 hasConceptScore W3143335768C119857082 @default.
• W3143335768 hasConceptScore W3143335768C126322002 @default.

• next