FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3143337327> ?p ?o ?g. }

• W3143337327 abstract "SUMMARY More than half of human tumors exhibit aberrantly dysregulated phosphoinositide signaling, yet how this is controlled remains not fully understood. While somatic mutations of PI3K, PTEN and Ras account for many cases of the hyperactivated lipid signals, other mechanisms for these dysfunctions in cancer are also being discovered. We report here that TNFAIP8 interacts with PtdIns(4,5) P 2 and PtdIns(3,4,5) P 3 and is likely to be hijacked by cancer cells to facilitate directional migration during malignant transformation. TNFAIP8 maintains the quiescent cellular state by sequestering inactive Rho GTPases in the cytosolic pool, which can be set free upon chemoattractant activation at the leading edge. Consequently, loss of TNFAIP8 results in severe defects of chemotaxis and adhesion. Thus, TNFAIP8, whose expression can be induced by inflammatory cytokines such as TNF α from tumor microenvironment, represents a molecular bridge from inflammation to cancer by linking NF-κB pathway to phosphoinositide signaling. Our study on the conserved hydrophobic cavity structure will also advise in silico drug screening and development of new TNFAIP8-based strategies to combat malignant human diseases." @default.
• W3143337327 created "2021-04-13" @default.
• W3143337327 creator A5003947656 @default.
• W3143337327 creator A5017373010 @default.
• W3143337327 creator A5050622568 @default.
• W3143337327 creator A5056747304 @default.
• W3143337327 creator A5087880097 @default.
• W3143337327 date "2021-03-26" @default.
• W3143337327 modified "2023-09-27" @default.
• W3143337327 title "TNFAIP8 is a novel phosphoinositide-binding inhibitory regulator of Rho GTPases that promotes cancer cell migration" @default.
• W3143337327 cites W14472107 @default.
• W3143337327 cites W1485829830 @default.
• W3143337327 cites W1504277962 @default.
• W3143337327 cites W1910650341 @default.
• W3143337327 cites W1966369019 @default.
• W3143337327 cites W1967265143 @default.
• W3143337327 cites W1967690338 @default.
• W3143337327 cites W1968826282 @default.
• W3143337327 cites W1976768672 @default.
• W3143337327 cites W1984630839 @default.
• W3143337327 cites W1985262467 @default.
• W3143337327 cites W1996335333 @default.
• W3143337327 cites W1997249154 @default.
• W3143337327 cites W2000035749 @default.
• W3143337327 cites W2004243782 @default.
• W3143337327 cites W2008177298 @default.
• W3143337327 cites W2011876929 @default.
• W3143337327 cites W2013071061 @default.
• W3143337327 cites W2020410964 @default.
• W3143337327 cites W2027612537 @default.
• W3143337327 cites W2031168104 @default.
• W3143337327 cites W2032575714 @default.
• W3143337327 cites W2035036469 @default.
• W3143337327 cites W2043312574 @default.
• W3143337327 cites W2044785751 @default.
• W3143337327 cites W2064815984 @default.
• W3143337327 cites W2066663644 @default.
• W3143337327 cites W2071876602 @default.
• W3143337327 cites W2080684797 @default.
• W3143337327 cites W2082012229 @default.
• W3143337327 cites W2095015521 @default.
• W3143337327 cites W2110866843 @default.
• W3143337327 cites W2160696686 @default.
• W3143337327 cites W2164495477 @default.
• W3143337327 cites W2168223794 @default.
• W3143337327 cites W2279317198 @default.
• W3143337327 cites W2335082578 @default.
• W3143337327 cites W2404243046 @default.
• W3143337327 cites W2479799737 @default.
• W3143337327 cites W2604317589 @default.
• W3143337327 cites W2736494644 @default.
• W3143337327 cites W2767191656 @default.
• W3143337327 cites W2897773842 @default.
• W3143337327 cites W3016699128 @default.
• W3143337327 cites W3149078497 @default.
• W3143337327 cites W4211214747 @default.
• W3143337327 cites W4255677297 @default.
• W3143337327 doi "https://doi.org/10.1101/2021.03.26.437243" @default.
• W3143337327 hasPublicationYear "2021" @default.
• W3143337327 type Work @default.
• W3143337327 sameAs 3143337327 @default.
• W3143337327 citedByCount "0" @default.
• W3143337327 crossrefType "posted-content" @default.
• W3143337327 hasAuthorship W3143337327A5003947656 @default.
• W3143337327 hasAuthorship W3143337327A5017373010 @default.
• W3143337327 hasAuthorship W3143337327A5050622568 @default.
• W3143337327 hasAuthorship W3143337327A5056747304 @default.
• W3143337327 hasAuthorship W3143337327A5087880097 @default.
• W3143337327 hasBestOaLocation W31433373271 @default.
• W3143337327 hasConcept C104317684 @default.
• W3143337327 hasConcept C121608353 @default.
• W3143337327 hasConcept C137738243 @default.
• W3143337327 hasConcept C1491633281 @default.
• W3143337327 hasConcept C170493617 @default.
• W3143337327 hasConcept C181199279 @default.
• W3143337327 hasConcept C185592680 @default.
• W3143337327 hasConcept C207332259 @default.
• W3143337327 hasConcept C2777609662 @default.
• W3143337327 hasConcept C502942594 @default.
• W3143337327 hasConcept C54166955 @default.
• W3143337327 hasConcept C54355233 @default.
• W3143337327 hasConcept C55493867 @default.
• W3143337327 hasConcept C62478195 @default.
• W3143337327 hasConcept C6929976 @default.
• W3143337327 hasConcept C86554907 @default.
• W3143337327 hasConcept C86803240 @default.
• W3143337327 hasConcept C95444343 @default.
• W3143337327 hasConcept C96232424 @default.
• W3143337327 hasConcept C98539663 @default.
• W3143337327 hasConceptScore W3143337327C104317684 @default.
• W3143337327 hasConceptScore W3143337327C121608353 @default.
• W3143337327 hasConceptScore W3143337327C137738243 @default.
• W3143337327 hasConceptScore W3143337327C1491633281 @default.
• W3143337327 hasConceptScore W3143337327C170493617 @default.
• W3143337327 hasConceptScore W3143337327C181199279 @default.
• W3143337327 hasConceptScore W3143337327C185592680 @default.
• W3143337327 hasConceptScore W3143337327C207332259 @default.
• W3143337327 hasConceptScore W3143337327C2777609662 @default.
• W3143337327 hasConceptScore W3143337327C502942594 @default.
• W3143337327 hasConceptScore W3143337327C54166955 @default.

• next