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• W3143342212 startingPage "1312" @default.
• W3143342212 abstract "The serine hydrolase (SH) superfamily is, perhaps, one of the largest functional enzyme classes in all forms of life and consists of proteases, peptidases, lipases, and carboxylesterases as representative members. Consistent with the name of this superfamily, all members, without any exception to date, use a nucleophilic serine residue in the enzyme active site to perform hydrolytic-type reactions via a two-step ping-pong mechanism involving a covalent enzyme intermediate. Given the highly conserved catalytic mechanism, this superfamily has served as a classical prototype in the development of several platforms of chemical proteomics techniques, activity-based protein profiling (ABPP), to globally interrogate the functions of its different members in various native, yet complex, biological settings. While ABPP-based proteome-wide activity atlases for SH activities are available in numerous organisms, including humans, to the best of our knowledge, such an analysis for this superfamily is lacking in any insect model. To address this, we initially report a bioinformatics analysis toward the identification and categorization of nonredundant SHs in Drosophila melanogaster. Following up on this in silico analysis, leveraging discovery chemoproteomics, we identify and globally map the full complement of SH activities during various developmental stages and in different adult tissues of Drosophila. Finally, as a proof of concept of the utility of this activity atlas, we highlight sexual dimorphism in SH activities across different tissues in adult D. melanogaster, and we propose new research directions, resources, and tools that this study can provide to the fly community." @default.
• W3143342212 created "2021-04-13" @default.
• W3143342212 creator A5033434804 @default.
• W3143342212 creator A5047121650 @default.
• W3143342212 creator A5052850826 @default.
• W3143342212 creator A5090405416 @default.
• W3143342212 date "2021-04-07" @default.
• W3143342212 modified "2023-09-30" @default.
• W3143342212 title "A Superfamily-wide Activity Atlas of Serine Hydrolases in <i>Drosophila melanogaster</i>" @default.
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• W3143342212 doi "https://doi.org/10.1021/acs.biochem.1c00171" @default.
• W3143342212 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7610703" @default.
• W3143342212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33827210" @default.
• W3143342212 hasPublicationYear "2021" @default.
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