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- W3143372881 abstract "Objective:To observe the rela tionship between the level of catecholam ine in plasma with bispectral index during endotracheal intubation with propofol anesthesia in order to investigate the mechanism of the preventing of endotrach eal intubation response with esmolol.Methods:Thirty patie nts were randomly allocated into two groups:control group(n=15)and esmolol group(n=15).The p atients received esmolol 1 mg/kg followed by 250 μg/(kg·min)in esmolol group and saline in control group.Two minutes later,the patient s received propofol 2 mg/kg for induction.Bispectral index(BIS),systoli c pressure(SP),diostolic pressure(DP),and heart rate(HR)were measured before endotracheal intubation and 3 min after intubation,at the same time 8 mL art eral blood was taken for the measurement of the concentrations of norephinephrine(NE)and ephinephrine(E)in plasma.Results:The level of BIS(63.53±3.11),NE(2.016±0.681)and E(0.578±0.072)in control group 3 min after endotracheal intu bation were increased significantly than those before intubation(P0.05),bu t there were no significant change in the level of BIS,NE and E in esmolol grou p 3 min after endotracheal intubation.There were significant differences i n the concentrations of NE(2.016±0.681)and E(0.578±0.072)in plasma 3 min aft er intubation between the two groups(P0.05)and there were also signific ant differences in BIS(63.53±3.11)and BIS(20.93±4.57)3 min after intubation b etween the two groups(P0.01).SP(148±20)and HR(89±180)in control grou p were increased after intubation than those before intubation(P0.05).Th ere were no significant differences in SP,DP and HR in esmolol group after intub ation than those before intubation.Conclusion:Esmolol can re duce the plasma co ncentrations of NE and E through preventing periopheal sympathetic nerve response to intubation and can reduce BIS arousal reactions after endotracheal intubatio n." @default.
- W3143372881 created "2021-04-13" @default.
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- W3143372881 date "2008-01-01" @default.
- W3143372881 modified "2023-09-22" @default.
- W3143372881 title "Mechanism of the preventing of endotracheal intubation response with esmolol-the relationship between the plasma catecholamine level and bispectral index" @default.
- W3143372881 hasPublicationYear "2008" @default.
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