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- W3143376624 abstract "Objective To characterize morphologically, immunophenotypically, cytogenetically and clinically the acute lymphoblastic leukemia (ALL) with t(4;11)(q21;q23). Methods Ten cases of t(4;11) ALL were reported. Of them, eight patients were de novo and two relapsed. The patients were treated with combination chemotherapy of DOPL or VP regimen. Immunophenotypic analysis was performed by flow cytometry in seven cases. Cytogenetic analysis was performed using bone marrow cells prepared directly and/or after 24h culture (case 7 using peripheral blood). RHG banding was used for karyotypic analysis. Results Ten (3.5%) of 285 ALL patients were found to be t(4;11) ALL. In these 10 patients, increased WBC(100×10 9/L) was found in 6 cases. Liver, spleen and/or lymph nodes were involved in all. t(4;11) was detected as a single abnormality in 5 karyotypes whereas the other 5 showed additional aberration besides t(4;11). Six patients were CD 19 (+),five were CD 22 (+) and one was HLA DR(+),CD 5(+), supporting that most cases of t(4;11) ALL were B cell origin. Median survival time was 5.5 months in the present series. Conclusion t(4;11) ALL was a subtype with unique clinical and cytogenetic features, and had a poor prognosis." @default.
- W3143376624 created "2021-04-13" @default.
- W3143376624 creator A5061801481 @default.
- W3143376624 date "2000-01-01" @default.
- W3143376624 modified "2023-09-28" @default.
- W3143376624 title "Chromosome t(4;11) acute lymphoblastic leukemia: an analysis of 10 cases" @default.
- W3143376624 hasPublicationYear "2000" @default.
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