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• W3143426729 abstract "<h2>Abstract</h2><h3>Purpose</h3> To investigate within phantoms the minimum CT dose allowed for accurate attenuation correction of PET data and to quantify the effective dose reduction when a CT for this purpose is incorporated in the clinical setting. <h3>Methods</h3> The NEMA image quality phantom was scanned within a large parallelepiped container. Twenty-one different CT images were acquired to correct attenuation of PET raw data. Radiation dose and image quality were evaluated. Thirty-one patients with proven multiple myeloma who underwent a dual tracer PET/CT scan were retrospectively reviewed. ¹⁸F-fluorodeoxyglucose PET/CT included a diagnostic whole-body low dose CT (WBLDCT: <i>120 kV-80mAs</i>) and ¹¹C-Methionine PET/CT included a whole-body ultra-low dose CT (WBULDCT) for attenuation correction (<i>100 kV-40mAs</i>). Effective dose and image quality were analysed. <h3>Results</h3> Only the two lowest radiation dose conditions (<i>80 kV-20mAs</i> and <i>80 kV-10mAs)</i> produced artifacts in CT images that degraded corrected PET images. For all the other conditions (CTDI_vol ≥ 0.43 mGy), PET contrast recovery coefficients varied less than ± 1.2%. Patients received a median dose of 6.4 mSv from diagnostic CT and 2.1 mSv from the attenuation correction CT. Despite the worse image quality of this CT, 94.8% of bone lesions were identifiable. <h3>Conclusion</h3> Phantom experiments showed that an ultra-low dose CT can be implemented in PET/CT procedures without any noticeable degradation in the attenuation corrected PET scan. The replacement of the standard CT for this ultra-low dose CT in clinical PET/CT scans involves a significant radiation dose reduction." @default.
• W3143426729 created "2021-04-13" @default.
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• W3143426729 date "2021-04-01" @default.
• W3143426729 modified "2023-10-18" @default.
• W3143426729 title "Ultra-low dose whole-body CT for attenuation correction in a dual tracer PET/CT protocol for multiple myeloma" @default.
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• W3143426729 doi "https://doi.org/10.1016/j.ejmp.2021.03.019" @default.
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