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- W3143452785 abstract "新鲜的水息肉水螅属于门 Cnidaria，它在 bilaterians 的外观前从后生动物的系分叉。以便在 metazoans 理解 apoptosis 的进化，我们开始阐明了在这个模型有机体的分子的细胞死亡机械。基于 EST 和整个水螅染色体集会，我们识别了 15 caspases。我们证明一个人在 apoptosis 期间被激活，四与 N 终端 DED，卡片或 DD 领域有开始者 caspases 的特征，二在 vitro 经历 autoprocessing。另外，我们描述七 Bcl-2-like 和二象 Bak 一样蛋白质。为大多数 Bcl-2 家庭蛋白质，我们观察了 mitochondrial 本地化。当在哺乳动物的房间表示了时，象 HyBak 一样 1 和 2 强烈导致的 apoptosis。禁止的 apoptosis 与显示出特别强壮的保护的效果的 HyBcl-2-like 4 在哺乳动物的房间由 camptothecin 劝诱了的六个 Bcl-2 家庭成员。这蛋白质也与象 HyBak 一样交往了 1 在酵母二混血儿的试金。在它的 BH3 领域的保存白氨酸的变化两个都与象 HyBak 一样废除了相互作用 1 并且 anti-apoptotic 效果。而且，我们 BH-3-only 描述新奇水螅蛋白质。这些之一与 Bcl-2-like 4 交往了并且在哺乳动物的房间导致了 apoptosis。我们的数据显示为房间死亡规定的一个复杂网络的进化在多细胞的组织的最早、最简单的水平产生了，它在此展出了一复杂性实质地高级比在 protostome 模型有机体 Caenorhabditis 和果蝇。" @default.
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- W3143452785 date "2010-01-01" @default.
- W3143452785 modified "2023-09-27" @default.
- W3143452785 title "The molecular cell death machinery in the simple cnidarian Hydra includes an expanded caspase family and pro-and anti-apoptotic Bcl-2 proteins" @default.
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