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- W3143468462 abstract "By integrating magnetic sensors and microfluidic system,a microfluidic magnetic bioprocessor was developed for the rapid determination of multi-target biomarkers.Three digestive system tumor makers(α-fetoprotein(AFP),carcinoembryonic antigen(CEA),carbohydrate antigen 19-9,(CA19-9) were simultaneously detected in the microchannel as a model system to evaluate this multi-target detection system performance.The experiment parameters including injecting flow velocity,the immune reaction time and rinsing rate for each step were optimized.In the microfluidic magnetic biosensor,standard curves were established for the detection of three tumor markers in serum samples,with the detection limits of 0.1 μg/L(CEA),0.1 μg/L(AFP),30 U/mL(CA19-9) and the dynamic ranges spanning four orders of magnitude.Multi-biomarker analysis could be completed within 30 min,and good linear correlations were obtained between the results of magnetic biosensor and ELISA method,while the former was with the advantage of fast detection and high sensitivity." @default.
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- W3143468462 date "2013-01-01" @default.
- W3143468462 modified "2023-09-25" @default.
- W3143468462 title "Development of Integrated Microfluidic Magnetic Biosensor for Multi-biomarker Detection" @default.
- W3143468462 doi "https://doi.org/10.3724/sp.j.1096.2013.30231" @default.
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