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• W3143488795 abstract "A team from Brigham and Women's Hospital in Boston recently published a secondary research analysis indicating that vitamin D supplementation was associated with an overall 17% risk reduction for advanced (metastatic or fatal) cancer. Research interest in this area was originally generated by previous epidemiological studies showing that people who live near the equator have a lower incidence of developing cancer and dying of certain cancers. Because these residents have greater sunlight exposure and thereby produce more vitamin D, investigators have theorized that vitamin D could be tied to their lower cancer risks. Paulette D. Chandler, MD, MPH, a primary care physician and epidemiologist in the Division of Preventive Medicine of Brigham and Women's Hospital, notes that vitamin D supplements are inexpensive and readily available and that the study provides important new information about its relationship with advanced cancer. The VITAL study was a placebo-controlled trial conducted for more than 5 years. It involved 25,000 participants: men aged 50 years or older and women aged 55 years or older who did not have cancer at the beginning of the study. The group was racially and ethnically diverse. Researchers tested the independent effects of both vitamin D and omega-3 supplements as well as possible synergy between them. The study included 4 different groups: vitamin D (2000 IU/d) plus omega-3s, vitamin D plus a placebo, omega-3s plus a placebo, and placebos for both. During the 5-year study period, 1617 participants were diagnosed with invasive cancer, including breast, prostate, colorectal, and lung cancer. Of the nearly 13,000 participants who received vitamin D, 226 were diagnosed with advanced cancer, whereas 274 who received the placebo were diagnosed with advanced cancer. Of the 7843 participants with a normal BMI (less than 25 kg/m) who were taking vitamin D, only 58 were diagnosed with an advanced cancer, whereas 96 participants who were taking the placebo were diagnosed with an advanced cancer. Researchers note that although the BMI connection could be coincidental, previous evidence does suggest a possible relationship between the two. Obesity and associated inflammation may reduce vitamin D's effectiveness as well as its receptor sensitivity, or it may alter vitamin D's signaling. Furthermore, randomized trials of vitamin D and type 2 diabetes have found evidence of vitamin D having a greater benefit for people at a normal weight while showing no benefit for obese patients. Vitamin D deficiency is common in patients with cancer, researchers add. One study, for example, reported rates of vitamin D deficiency in patients with cancer as high as 72%." @default.
• W3143488795 created "2021-04-13" @default.
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• W3143488795 date "2021-04-01" @default.
• W3143488795 modified "2023-09-23" @default.
• W3143488795 title "Supplemental Vitamin D may reduce advanced cancer risk" @default.
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• W3143488795 doi "https://doi.org/10.1002/cncr.33521" @default.
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