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- W3143506350 endingPage "103" @default.
- W3143506350 startingPage "97" @default.
- W3143506350 abstract "The human immune system is in continuous interaction with environmental factors (pathogens, exercise, stress, pollutants, diet, vaccines, and therapeutics) that condition its efficiency by promoting or moderating multiple immune mechanisms. While the deleterious impact of external factors can be avoided or limited, the immune system itself grows weaker with age. Immune cells persist in the elderly, and the observed decline of cellular immunity is related to cellular senescence. Immunosenescence, which affects both T and B cells, erodes lymphocyte-dependent responses to vaccines and pathogens. Germinal centers (GCs), the organized lymphoid structures where B cells engage in affinity maturation, are regulated by follicular helper (Tfh) and follicular regulatory (Tfr) T cells, the major T cell components of GCs. This review discusses how age-related changes affect Tfh and Tfr cells as key components of B cell immunity, and how they ultimately shape the response of the ageing immune system to vaccines and infectious challenges." @default.
- W3143506350 created "2021-04-13" @default.
- W3143506350 creator A5015707587 @default.
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- W3143506350 creator A5043518408 @default.
- W3143506350 creator A5072183833 @default.
- W3143506350 creator A5091882026 @default.
- W3143506350 date "2021-05-01" @default.
- W3143506350 modified "2023-10-18" @default.
- W3143506350 title "Ageing of T-dependent B cell responses" @default.
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- W3143506350 doi "https://doi.org/10.1016/j.imlet.2021.03.012" @default.
- W3143506350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33811941" @default.
- W3143506350 hasPublicationYear "2021" @default.
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