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- W3143507973 startingPage "307" @default.
- W3143507973 abstract "As a major threat factor for female health, breast cancer (BC) has garnered a lot of attention for its malignancy and diverse molecules participating in its carcinogenesis process. Among these complex carcinogenesis processes, cell proliferation, epithelial-to-mesenchymal transition (EMT), mesenchymal-to-epithelial transition (MET), and angiogenesis are the major causes for the occurrence of metastasis and chemoresistance which account for cancer malignancy. MicroRNAs packaged and secreted in exosomes are termed “exosomal microRNAs (miRNAs)”. Nowadays, more researches have uncovered the roles of exosomal miRNAs played in BC metastasis. In this review, we recapitulated the dual actions of exosomal miRNAs exerted in the aggressiveness of BC by influencing migration, invasion, and distant metastasis. Next, we presented how exosomal miRNAs modify angiogenesis and stemness maintenance. Clinically, several exosomal miRNAs can govern the transformation between drug sensitivity and chemoresistance. Since the balance of the number and type of exosomal miRNAs is disturbed in pathological conditions, they are able to serve as instructive biomarkers for BC diagnosis and prognosis. More efforts are needed to connect the theoretical studies and clinical traits together. This review provides an outline of the pleiotropic impacts of exosomal miRNAs on BC metastasis and their clinical implications, paving the way for future personalized drugs." @default.
- W3143507973 created "2021-04-13" @default.
- W3143507973 creator A5006677940 @default.
- W3143507973 creator A5011009858 @default.
- W3143507973 creator A5018566664 @default.
- W3143507973 creator A5018774424 @default.
- W3143507973 creator A5029667848 @default.
- W3143507973 creator A5046465285 @default.
- W3143507973 creator A5058808586 @default.
- W3143507973 creator A5091352985 @default.
- W3143507973 date "2021-04-07" @default.
- W3143507973 modified "2023-10-15" @default.
- W3143507973 title "Exosomal microRNAs: Pleiotropic Impacts on Breast Cancer Metastasis and Their Clinical Perspectives" @default.
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