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• W3143516539 endingPage "151739" @default.
• W3143516539 startingPage "151739" @default.
• W3143516539 abstract "We investigated the expression of LGR5, the most robust and reliable known cancer stem cell (CSC) marker of colorectal cancer, and PD-L1 in tumor budding (TB), as well as clinicopathological features. Tissue microarrays (TMAs) were generated from TB samples from 32 stage II/III colorectal adenocarcinoma patients, and LGR5 expression in TMAs was evaluated by RNAscope, an extremely sensitive RNA in situ hybridization technique. LGR5 expression was significantly lower in the PD-L1-positive group than in the PD-L1-negative group (P = 0.0256). In the PD-L1-positive group, the tumor-infiltrating lymphocytes (TILs) score tended to be higher while the TNM stage was lower compared with the PD-L1 negative group (P = 0.0822 and P = 0.0765, respectively). There was no significant difference in Overall Survival between the PD-L1-positive and PD-L1-negative groups (log-rank test, P = 0.8218). This study showed that PD-L1-positive patients are a unique population with low LGR5 expression, and that LGR5-positive cells may be a promising therapeutic target in PD-L1-negative patients." @default.
• W3143516539 created "2021-04-13" @default.
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• W3143516539 date "2021-06-01" @default.
• W3143516539 modified "2023-10-03" @default.
• W3143516539 title "Inverse correlation between PD-L1 expression and LGR5 expression in tumor budding of stage II/III colorectal cancer" @default.
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• W3143516539 doi "https://doi.org/10.1016/j.anndiagpath.2021.151739" @default.
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