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- W3143554501 abstract "Objective To study relation of the expression of hTERT mRNA and cyclin A, p53 protein, proliferation cell nuclear antigen (PCNA)in ameloblastoma (AB) and to investigate clinical biological characteristics of AB Methods The hTERT mRNA was detected by in situ hybridization, cyclin A , p53 protein and PCNA by SP method Normal oral mucosa and odontogenic keratocyst(OKC) are comparition Results The positive ratio of hTERT mRNA was 1/7 cases in normal oral mucosa The expression of cyclin A, p53 and PCNA in normal oral mucosa were similar, and the positive cells distributed in stratum basale In OKC, the positive cells distributed in stratum basale and super strrtum basale And the positive ratio of hTERT, cyclin A, p53, PCNA in OKC was 14/16 cases, 4/32 cases, 11/25 cases, 5/9 cases, respectively In AB, the positive ratio of hTERT mRNA, cyclin A, p53 protein and PCNA was 94 4%(51/54), 66 7%(40/60), 85 7%(42/49) and 78 1%(25/32), respectively A strong correlation was found between hTERT mRNA with cyclin A, p53 protein and PCNA ( r s =0 914, 0 848, 0 804, P 0 05) Conclusions The expression of hTETR mRNA, cyclin A, p53 and PCNA is different in different tissues and lesions, and correlates with cell differentiation and clinical biology behaviour Telomerase activity is related to cumulation of p53 protein, related to cell proliferation and differentiation, regulated by cyclin A, and higher in S phase" @default.
- W3143554501 created "2021-04-13" @default.
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- W3143554501 date "2003-01-01" @default.
- W3143554501 modified "2023-09-24" @default.
- W3143554501 title "Expression of telomerase activity and cyclin A in ameloblastoma" @default.
- W3143554501 hasPublicationYear "2003" @default.
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