Matches in SemOpenAlex for { <https://semopenalex.org/work/W3143565534> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W3143565534 endingPage "613" @default.
- W3143565534 startingPage "608" @default.
- W3143565534 abstract "TMTP1, a 5-amino acid peptide NVVRQ, obtained by using the flagella peptide library screening in our previous studies, can be used for the labeling of malignant in situ and metastatic lesions, and even micro-metastases. In this study, TMTP1 was assessed for its ability to specifically target the malignant hematopoietic cells and metastatic lesions of hematological malignancies. FITC-TMTP1 was chemically synthesized. Immunofluorescence assay and competitive test were carried out to determine the specific binding capacity of TMTPl to hematological malignant cell lines, including HL60, k562, SHI-1, Jurkat, Raji, El-4 and umbilical cord blood mononuclear cells. Mononuclear cells were isolated from the bone marrow of healthy subjects and patients with chronic myeloid leukemia. Then the cells were co-clutured with TMTP1 or scrambled peptides and the binding and affinity of TMTP1 peptide to the primary cells of hematological malignancies were flow cytometrically analyzed. The binding speci-ficity of TMTP1 to target hematological malignancies was measured in vivo by intravenous injection of FITC-conjugated TMTP1 into El-4 lymphoma-bearing mice. The results showed that TMTP1 specifi-cally bound to the cells of a series of hematological malignancies, including HL60, k562, Jurkat, Raji , El-4 and chronic myeloid leukemia primary cells but not to bone marrow mononuclear cells from healthy subjects. By contrast, TMTP1 could bind to the metastatic foci of lymphoma originating from the EL-4 cell line while the scrambled peptide failed to do so. Moreover, the occult metastases could be identified, with high specificity, by detecting FITC-TMTP1. We are led to conclude that TMTP1, as a novel tumor-homing peptide, can serve as a marker for primary malignant and metastatic lesions for the early diagnosis of hematological malignances and a carrier of anticancer drugs for cancer treatment." @default.
- W3143565534 created "2021-04-13" @default.
- W3143565534 creator A5021451914 @default.
- W3143565534 creator A5034302055 @default.
- W3143565534 creator A5046289888 @default.
- W3143565534 creator A5060601776 @default.
- W3143565534 creator A5062390187 @default.
- W3143565534 creator A5063405571 @default.
- W3143565534 creator A5070762282 @default.
- W3143565534 creator A5074826925 @default.
- W3143565534 creator A5087243621 @default.
- W3143565534 date "2011-01-01" @default.
- W3143565534 modified "2023-09-28" @default.
- W3143565534 title "TMTP1, a Novel Tumor-homing Peptide, Specifically Targets Hematological Malignancies and Their Metastases" @default.
- W3143565534 hasPublicationYear "2011" @default.
- W3143565534 type Work @default.
- W3143565534 sameAs 3143565534 @default.
- W3143565534 citedByCount "0" @default.
- W3143565534 crossrefType "journal-article" @default.
- W3143565534 hasAuthorship W3143565534A5021451914 @default.
- W3143565534 hasAuthorship W3143565534A5034302055 @default.
- W3143565534 hasAuthorship W3143565534A5046289888 @default.
- W3143565534 hasAuthorship W3143565534A5060601776 @default.
- W3143565534 hasAuthorship W3143565534A5062390187 @default.
- W3143565534 hasAuthorship W3143565534A5063405571 @default.
- W3143565534 hasAuthorship W3143565534A5070762282 @default.
- W3143565534 hasAuthorship W3143565534A5074826925 @default.
- W3143565534 hasAuthorship W3143565534A5087243621 @default.
- W3143565534 hasConcept C137061746 @default.
- W3143565534 hasConcept C142724271 @default.
- W3143565534 hasConcept C151872237 @default.
- W3143565534 hasConcept C171122931 @default.
- W3143565534 hasConcept C179464577 @default.
- W3143565534 hasConcept C18903297 @default.
- W3143565534 hasConcept C202751555 @default.
- W3143565534 hasConcept C203014093 @default.
- W3143565534 hasConcept C2776090121 @default.
- W3143565534 hasConcept C2778461978 @default.
- W3143565534 hasConcept C2778903051 @default.
- W3143565534 hasConcept C2779338263 @default.
- W3143565534 hasConcept C2780007613 @default.
- W3143565534 hasConcept C502942594 @default.
- W3143565534 hasConcept C55493867 @default.
- W3143565534 hasConcept C71924100 @default.
- W3143565534 hasConcept C86803240 @default.
- W3143565534 hasConcept C8891405 @default.
- W3143565534 hasConceptScore W3143565534C137061746 @default.
- W3143565534 hasConceptScore W3143565534C142724271 @default.
- W3143565534 hasConceptScore W3143565534C151872237 @default.
- W3143565534 hasConceptScore W3143565534C171122931 @default.
- W3143565534 hasConceptScore W3143565534C179464577 @default.
- W3143565534 hasConceptScore W3143565534C18903297 @default.
- W3143565534 hasConceptScore W3143565534C202751555 @default.
- W3143565534 hasConceptScore W3143565534C203014093 @default.
- W3143565534 hasConceptScore W3143565534C2776090121 @default.
- W3143565534 hasConceptScore W3143565534C2778461978 @default.
- W3143565534 hasConceptScore W3143565534C2778903051 @default.
- W3143565534 hasConceptScore W3143565534C2779338263 @default.
- W3143565534 hasConceptScore W3143565534C2780007613 @default.
- W3143565534 hasConceptScore W3143565534C502942594 @default.
- W3143565534 hasConceptScore W3143565534C55493867 @default.
- W3143565534 hasConceptScore W3143565534C71924100 @default.
- W3143565534 hasConceptScore W3143565534C86803240 @default.
- W3143565534 hasConceptScore W3143565534C8891405 @default.
- W3143565534 hasIssue "5" @default.
- W3143565534 hasLocation W31435655341 @default.
- W3143565534 hasOpenAccess W3143565534 @default.
- W3143565534 hasPrimaryLocation W31435655341 @default.
- W3143565534 hasRelatedWork W1144511227 @default.
- W3143565534 hasRelatedWork W142345009 @default.
- W3143565534 hasRelatedWork W1557355972 @default.
- W3143565534 hasRelatedWork W2012715810 @default.
- W3143565534 hasRelatedWork W2033938517 @default.
- W3143565534 hasRelatedWork W2095036378 @default.
- W3143565534 hasRelatedWork W2112519125 @default.
- W3143565534 hasRelatedWork W2129645836 @default.
- W3143565534 hasRelatedWork W2155366350 @default.
- W3143565534 hasRelatedWork W2166440745 @default.
- W3143565534 hasRelatedWork W2171391788 @default.
- W3143565534 hasRelatedWork W2283552552 @default.
- W3143565534 hasRelatedWork W2328489610 @default.
- W3143565534 hasRelatedWork W2418724142 @default.
- W3143565534 hasRelatedWork W2492731544 @default.
- W3143565534 hasRelatedWork W2563569306 @default.
- W3143565534 hasRelatedWork W2954970830 @default.
- W3143565534 hasRelatedWork W2987928837 @default.
- W3143565534 hasRelatedWork W2988188154 @default.
- W3143565534 hasRelatedWork W2988518539 @default.
- W3143565534 hasVolume "31" @default.
- W3143565534 isParatext "false" @default.
- W3143565534 isRetracted "false" @default.
- W3143565534 magId "3143565534" @default.
- W3143565534 workType "article" @default.