Matches in SemOpenAlex for { <https://semopenalex.org/work/W3143568658> ?p ?o ?g. }
- W3143568658 endingPage "2631" @default.
- W3143568658 startingPage "2615" @default.
- W3143568658 abstract "Plumbagin, a naphthoquinone extracted from the officinal leadwort presenting promising anti-cancer properties, has its therapeutic potential limited by its inability to reach tumors in a specific way at a therapeutic concentration following systemic injection. The purpose of this study is to assess whether a novel tumor-targeted, lipid-polymer hybrid nanoparticle formulation of plumbagin would suppress the growth of B16-F10 melanoma in vitro and in vivo.Novel lipid-polymer hybrid nanoparticles entrapping plumbagin and conjugated with transferrin, whose receptors are present in abundance on many cancer cells, have been developed. Their cellular uptake, anti-proliferative and apoptosis efficacy were assessed on various cancer cell lines in vitro. Their therapeutic efficacy was evaluated in vivo after tail vein injection to mice bearing B16-F10 melanoma tumors.The transferrin-bearing lipid-polymer hybrid nanoparticles loaded with plumbagin resulted in the disappearance of 40% of B16-F10 tumors and regression of 10% of the tumors following intravenous administration. They were well tolerated by the mice.These therapeutic effects, therefore, make transferrin-bearing lipid-polymer hybrid nanoparticles entrapping plumbagin a highly promising anti-cancer nanomedicine." @default.
- W3143568658 created "2021-04-13" @default.
- W3143568658 creator A5009502942 @default.
- W3143568658 creator A5011774162 @default.
- W3143568658 creator A5025442498 @default.
- W3143568658 creator A5051380891 @default.
- W3143568658 creator A5084165213 @default.
- W3143568658 date "2021-04-01" @default.
- W3143568658 modified "2023-10-12" @default.
- W3143568658 title "Regression of Melanoma Following Intravenous Injection of Plumbagin Entrapped in Transferrin-Conjugated, Lipid–Polymer Hybrid Nanoparticles" @default.
- W3143568658 cites W1545799600 @default.
- W3143568658 cites W177421999 @default.
- W3143568658 cites W1775749144 @default.
- W3143568658 cites W1776205939 @default.
- W3143568658 cites W1952221220 @default.
- W3143568658 cites W1963675633 @default.
- W3143568658 cites W1964429118 @default.
- W3143568658 cites W1965742680 @default.
- W3143568658 cites W1972398280 @default.
- W3143568658 cites W1982258251 @default.
- W3143568658 cites W1988479401 @default.
- W3143568658 cites W1993456710 @default.
- W3143568658 cites W1993718440 @default.
- W3143568658 cites W2002516695 @default.
- W3143568658 cites W2007851654 @default.
- W3143568658 cites W2010887032 @default.
- W3143568658 cites W2010976109 @default.
- W3143568658 cites W2011934424 @default.
- W3143568658 cites W2013262011 @default.
- W3143568658 cites W2013780909 @default.
- W3143568658 cites W2019607817 @default.
- W3143568658 cites W2020402485 @default.
- W3143568658 cites W2027437657 @default.
- W3143568658 cites W2029181073 @default.
- W3143568658 cites W2037407093 @default.
- W3143568658 cites W2047219204 @default.
- W3143568658 cites W2047695681 @default.
- W3143568658 cites W2061372618 @default.
- W3143568658 cites W2067354626 @default.
- W3143568658 cites W2070803838 @default.
- W3143568658 cites W2075204828 @default.
- W3143568658 cites W2075408635 @default.
- W3143568658 cites W2075978239 @default.
- W3143568658 cites W2082980465 @default.
- W3143568658 cites W2093523702 @default.
- W3143568658 cites W2094350446 @default.
- W3143568658 cites W2106543868 @default.
- W3143568658 cites W2116346856 @default.
- W3143568658 cites W2124357214 @default.
- W3143568658 cites W2143463421 @default.
- W3143568658 cites W2162669933 @default.
- W3143568658 cites W2170952917 @default.
- W3143568658 cites W2227263789 @default.
- W3143568658 cites W2331692879 @default.
- W3143568658 cites W2333479431 @default.
- W3143568658 cites W2414781026 @default.
- W3143568658 cites W2513212960 @default.
- W3143568658 cites W2564180590 @default.
- W3143568658 cites W2607225440 @default.
- W3143568658 cites W2737243453 @default.
- W3143568658 cites W2802433717 @default.
- W3143568658 cites W2811122211 @default.
- W3143568658 cites W2966011815 @default.
- W3143568658 cites W2969201856 @default.
- W3143568658 cites W2996925188 @default.
- W3143568658 doi "https://doi.org/10.2147/ijn.s293480" @default.
- W3143568658 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8039437" @default.
- W3143568658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33854311" @default.
- W3143568658 hasPublicationYear "2021" @default.
- W3143568658 type Work @default.
- W3143568658 sameAs 3143568658 @default.
- W3143568658 citedByCount "12" @default.
- W3143568658 countsByYear W31435686582022 @default.
- W3143568658 countsByYear W31435686582023 @default.
- W3143568658 crossrefType "journal-article" @default.
- W3143568658 hasAuthorship W3143568658A5009502942 @default.
- W3143568658 hasAuthorship W3143568658A5011774162 @default.
- W3143568658 hasAuthorship W3143568658A5025442498 @default.
- W3143568658 hasAuthorship W3143568658A5051380891 @default.
- W3143568658 hasAuthorship W3143568658A5084165213 @default.
- W3143568658 hasBestOaLocation W31435686581 @default.
- W3143568658 hasConcept C121608353 @default.
- W3143568658 hasConcept C126322002 @default.
- W3143568658 hasConcept C15083742 @default.
- W3143568658 hasConcept C150903083 @default.
- W3143568658 hasConcept C155672457 @default.
- W3143568658 hasConcept C171250308 @default.
- W3143568658 hasConcept C185592680 @default.
- W3143568658 hasConcept C190283241 @default.
- W3143568658 hasConcept C192562407 @default.
- W3143568658 hasConcept C202751555 @default.
- W3143568658 hasConcept C207001950 @default.
- W3143568658 hasConcept C22814914 @default.
- W3143568658 hasConcept C26291073 @default.
- W3143568658 hasConcept C2777658100 @default.
- W3143568658 hasConcept C2780532915 @default.
- W3143568658 hasConcept C502942594 @default.
- W3143568658 hasConcept C54355233 @default.