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- W3143580946 abstract "Significance R-loop structures pose a threat to genomic integrity because their formation can lead to mutagenesis. Mutagenesis drives antibiotic resistance in bacteria and chemotherapy resistance in human cancers; therefore, it is important to understand how R-loops form. Using a combination of in vitro single-molecule experimentation and in vivo mutagenesis assays, we have shown how Mfd, a bacterial protein known for its role in DNA repair, can interact with RNA polymerase to form R-loops. This interaction generates a topological domain in DNA that is highly prone to R-loop formation. The observed mechanism relies on properties of Mfd that are shared by many other proteins, hinting that this is a potentially universal model for R-loop formation." @default.
- W3143580946 created "2021-04-13" @default.
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- W3143580946 date "2021-04-07" @default.
- W3143580946 modified "2023-10-17" @default.
- W3143580946 title "Cotranscriptional R-loop formation by Mfd involves topological partitioning of DNA" @default.
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- W3143580946 doi "https://doi.org/10.1073/pnas.2019630118" @default.
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