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- W3143600493 abstract "瞄准：评估人的白血球的协会有通过出版数据的元分析的 hepatocellular 癌(HCC ) 的抗原(HLA )-DQB1 等位基因。方法：有出版直到 2010 年 1 月的 HCC 的 HLA-DQB1 等位基因协会上的盒子控制研究在分析被包括。在 HCC 病人的 HLA-DQB1 等位基因分布的机会比率(ORs ) 被分析并且与健康控制相比。元分析软件 REVMAN 5.0 被申请在单个研究之中并且为总结所有研究调查异质。元分析用改正效果或随机效果的方法被执行，取决于重要异质的缺席或存在。包含 398 个案例和 594 控制的七盒子控制研究总之被包括。结果：在五家庭等位基因之中，(DQB1 *02 和 DQB1 *03 ) 二被发现显著地与 HCC 的风险被联系。联合或为有为 HCC 的风险的 DQB1 *02 和 DQB1 *03 等位基因的协会是 1.78 (95% CI：1.05-3.03， P = 0.03 ) 并且 0.65 (95% CI：0.48-0.89， P = 0.007 ) 分别地。在 13 特定的等位基因之中，(DQB1 *0502 和 DQB1 *0602 ) 二显著地与 HCC 的风险被联系。联合或为有为 HCC 的风险的 DQB1 *0502 和 DQB1 *0602 等位基因的协会是 1.82 (95% CI：1.14-2.92， P = 0.01 ) 并且 0.58 (95% CI：0.36-0.95， P = 0.03 ) 分别地。没有重要协会为另外的 HLA-DQB1 家庭等位基因和特定的等位基因被建立。结论：我们的结果支持特定的 HLA-DQB1 等位基因家庭和等位基因可能影响的假设危险性或抵抗到 HCC，尽管它需要进一步的调查。" @default.
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- W3143600493 date "2011-01-01" @default.
- W3143600493 modified "2023-09-27" @default.
- W3143600493 title "Specific HLA-DQB1 alleles associated with risk for development of hepatocellular carcinoma：A meta-analysis" @default.
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