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- W3143600666 abstract "MicroRNA alterations have been reported in patients with Alzheimer ’s disease(AD) and AD mouse models. We now report that miR-206 is upregulated in the hippocampal tissue, cerebrospinal fluid, and plasma of embryonic APP/PS1 transgenic mice. The increased miR-206 downregulates the expression of brain-derived neurotrophic factor(BDNF). BDNF is neuroprotective against cell death after various insults, but in embryonic and newborn APP/PS1 mice it is decreased. Thus, a specifi c microRNA alteration may contribute to AD pathology by downregulating BDNF." @default.
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- W3143600666 date "2014-01-01" @default.
- W3143600666 modified "2023-09-23" @default.
- W3143600666 title "MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse model of Alzheimer＇s disease" @default.
- W3143600666 hasPublicationYear "2014" @default.
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