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- W3143621787 abstract "因为 Mycobacterium bovis 杆菌 CalmetteGuerin 紧张(BCG ) 没能保护成年人免受肺的肺结核(TB ) 的伤害，对开发一支新疫苗有迫切需要。在这研究，我们构造了表示人的 granulocyte 巨噬细胞的一个新奇 recombinant BCG 种类( rBCG )刺激殖民地的因素( GM-CSF )和 6 kDa Mycobacterium 肺结核的早能分泌的 antigenic 目标( ESAT6 )，命名 rBCG : GE (表示 GMCSF-ESAT6 建筑群)，并且在 BALB/c 老鼠评估了构造的 immunogenicity 。我们的结果显示 rBCG : GE 能比常规 BCG 导致抗体的更高的 titer， rBCG : G (表示 GM-CSF ) 和 rBCG : E (表示 ESAT6 ) 。而且， rBCG : GE 也得到了长持续、更强壮的 Th1 细胞的有免疫力的回答比另外的组，被 splenocytes 的增长增长证实，怒气的CD4+和CD8+ T 房间的增加的百分比，干扰素的提高的水平--在在净化结核菌素的蛋白质衍生物刺激，和在浆液的 GM-CSF 的增加的集中以后的 splenocyte 文化。这里介绍的数据建议了可能性 recombinant BCG : GE 可能是到 TB 的一个好疫苗的候选人。" @default.
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- W3143621787 date "2011-01-01" @default.
- W3143621787 modified "2023-09-24" @default.
- W3143621787 title "A novel recombinant Mycobacterium bovis bacillus Calmette-Guerin strain expressing human granulocyte macrophage colony-stimulating factor and Mycobacterium tuberculosis early secretory antigenic target 6 complex augments Thl immunity" @default.
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