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- W3143640432 abstract "ABSTRACT The migration of activated T cells across the blood–brain barrier (BBB) is a critical step in central nervous system (CNS) immune surveillance and inflammation. Whereas T cell diapedesis across the intact BBB seems to occur preferentially through the BBB cellular junctions, impaired BBB integrity during neuroinflammation is accompanied by increased transcellular T cell diapedesis. The underlying mechanisms directing T cells to paracellular versus transcellular sites of diapedesis across the BBB remain to be explored. By combining in vitro live-cell imaging of T cell migration across primary mouse brain microvascular endothelial cells (pMBMECs) under physiological flow with serial block-face scanning electron microscopy (SBF-SEM), we have identified BBB tricellular junctions as novel sites for T cell diapedesis across the BBB. Downregulated expression of tricellular junctional proteins or protein-based targeting of their interactions in pMBMEC monolayers correlated with enhanced transcellular T cell diapedesis, and abluminal presence of chemokines increased T cell diapedesis through tricellular junctions. Our observations assign an entirely novel role to BBB tricellular junctions in regulating T cell entry into the CNS. This article has an associated First Person interview with the first author of the paper." @default.
- W3143640432 created "2021-04-13" @default.
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- W3143640432 date "2021-04-15" @default.
- W3143640432 modified "2023-10-15" @default.
- W3143640432 title "Brain endothelial tricellular junctions as novel sites for T cell diapedesis across the blood–brain barrier" @default.
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- W3143640432 doi "https://doi.org/10.1242/jcs.253880" @default.
- W3143640432 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8121105" @default.
- W3143640432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33912914" @default.
- W3143640432 hasPublicationYear "2021" @default.
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