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- W3143647966 abstract "Objective To investigate the HIV-1 nef specific CD8 + T cell responses in long-term nonprogressor (LTNP) and AIDS patient in China.Methods Peripheral blood mononuclear cells were collected from 7 LTNPs and 9 AIDS patients, 12 males and 4 females, aged 37 (27～55). A panel of 26 overlapping peptides spanning HIV-1 nef constituting 3 peptide pools was used as antigens. The HIV-1 nef specific CD8 + T cell responses of the LTNPs and AIDS patients were examined by IFN- ELISPOT assay. The amount of CD4 + T cell and viral load were detected. The relationships between HIV-1 nef specific CD8 + T cell responses and CD4 + T cell counts and viral loads were studied.Results The strength of HIV-1 nef specific CD8 + T cell responses of LTNP group was 404±33 SFC/10 6 PBMCs, significantly higher than that of the AIDS group (59±121 SFC/10 6 PBMCs ). The strength of HIV-1 nef specific CD8 + T cell responses was positively correlated with the CD4 + T cell count. No relationship between the strength of CD8 + T cell responses and viral load was found.Conclusion HIV-1 nef specific CD8 + T cell responses may play an important role in preventing disease progression of HIV infection. There is a cross immune response between the major HIV-1 strains in Europe and those in China ." @default.
- W3143647966 created "2021-04-13" @default.
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- W3143647966 date "2004-01-01" @default.
- W3143647966 modified "2023-09-29" @default.
- W3143647966 title "HIV-1 nef specific cytotoxic T lymphocyte responses in long-term nonprogressors and AIDS patients" @default.
- W3143647966 hasPublicationYear "2004" @default.
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