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- W3143654807 abstract "BACKGROUNDActivated protein C, the body's natural anticoagulant, may play a role in protecting the heart during and following an occlusion of the left anterior descending coronary artery (LAD) in the porcine heart.METHODS AND RESULTSInfusion of 1 unit thrombin over 30 seconds into the LAD of juvenile pigs produced a prolongation of the Xa clotting time (153 +/- 14%) in blood drawn from the anterior interventricular vein (AIV). The action of the anticoagulant was blocked by a polyclonal immunoglobulin G antibody directed against porcine activated protein C. A brief (30 seconds) occlusion of the LAD induced a similar prolongation of the Xa clotting time (138 +/- 11%), which was also blocked by the polyclonal antibody. To determine whether activated protein C helps sustain the heart during and following a 2-minute occlusion, three groups of pigs were studied: 11 controls, six receiving activated porcine protein C, and nine receiving a monoclonal antibody (HPC4) that blocks protein C activation. Relative to t..." @default.
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- W3143654807 date "1991-01-01" @default.
- W3143654807 modified "2023-09-26" @default.
- W3143654807 title "Protein C activation following coronary artery occlusion in the in situ porcine heart." @default.
- W3143654807 hasPublicationYear "1991" @default.
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