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- W3143672382 abstract "Purpose We compared the contrast effect of three doses of DD-723 in subjects with breast tumors to determine the recommended dose. We then evaluated differential diagnosis results using plain ultrasonography, contrastenhanced ultrasonography (plain ? enhanced), and contrast-enhanced magnetic resonance imaging (MRI) compared to the pathological diagnosis. Methods To evaluate the contrast effect, contrastenhanced ultrasonic images were independently evaluated in a randomized sequence by three blinded reviewers trained in the evaluation method beforehand. Multiple evaluation results from the three reviewers were used to assess the overall contrast effect. The differential diagnosis was evaluated independently by three blinded reviewers using contrast-enhanced ultrasonic images and contrast-enhanced magnetic resonance images in a randomized sequence; reviewers were also blinded to subject characteristics. Multiple evaluation results from the three reviewers were used to assess the overall differential diagnosis. Results The recommended dose of DD-723 is an intermediate dose of 0.12 lL MB/kg. Accuracy, sensitivity, and specificity were improved more in the differential diagnosis by contrast-enhanced ultrasonography than in plain ultrasonography. Accuracy and specificity were better and sensitivity similar compared to contrast-enhanced MRI. Conclusions An intermediate dose showed the highest efficacy in terms of overall contrast effect. Contrastenhanced ultrasonography is safe and useful when used in differential diagnosis." @default.
- W3143672382 created "2021-04-13" @default.
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- W3143672382 date "2012-01-01" @default.
- W3143672382 modified "2023-09-27" @default.
- W3143672382 title "Phase II clinical study of DD-723 (perflubutane): dose-response study in patients with breast tumors" @default.
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