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- W3143726119 abstract "Objective:To investigate the protective effect of penehvclidine hvdrochloride on ischemiareperfusion injury in rats.Method:The model of ischemia-reperniston injury was established in rats through clamping rental pedicles for SO min followed by reperfusion.A total of 60 Wistar rats were randomly divided.into 4 groups including fake surgery group,model group,low PHC dosage group and high dosage penehvclidine hvdrochloride(PHC)group.Seven days before the experiment,rats in fake surgery group and model group were given 10 mL/kg normal saline,while rats in low PHC dosage group and high dosage PHC group were given 200 and SO mg/kg PHC,respectively.The urine volume,diet volume,Cre,PU,BUN,IL-6,IL-8,TNF-α,NO MDA concentration,SOD and GSH-Px were determined.Results:Compared with rats in model group,decreased urine volume,diet volume,Cre,PU,BUN,IL-6,IL-8,TNF-α,NO MDA concentration and increased SOD and CSH-Px activity could be seen in low PHC dosage group and high dosage PHC group(P<0.05).Conclusions:Administration of PHC before ischemia-reperfusion injury can help protect ischemia-reperfusion injury." @default.
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- W3143726119 date "2014-01-01" @default.
- W3143726119 modified "2023-09-22" @default.
- W3143726119 title "Protective effect of penehvclidine hvdrochloride on ischemiareperfusion injury in rats" @default.
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