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- W3143731966 endingPage "21.2021" @default.
- W3143731966 startingPage "ENEURO.0052" @default.
- W3143731966 abstract "Abstract Alcohol dependence can result in long-lasting deficits to decision-making and action control. Neurobiological investigations have identified orbitofrontal cortex (OFC) as important for outcome-related contributions to goal-directed actions during decision-making. Prior work has shown that alcohol dependence induces long-lasting changes to OFC function that persist into protracted withdrawal and disrupts goal-directed control over actions. However, it is unclear whether these changes in function alter representation of action and outcome-related neural activity in OFC. Here, we used the well-validated chronic intermittent ethanol (CIE) exposure and withdrawal procedure to model alcohol dependence in mice and performed in vivo extracellular recordings during an instrumental task in which lever-press actions made for a food outcome. We found alcohol dependence disrupted goal-directed action control and increased OFC activity associated with lever-pressing but decreased OFC activity during outcome-related epochs. The ability to decode outcome-related information, but not action information, from OFC activity following CIE exposure was reduced. Hence, chronic alcohol exposure induced a long-lasting disruption to OFC function such that activity associated with actions was enhanced, but OFC activity contributions to outcome-related information was diminished. This has important implications for hypotheses regarding compulsive and habitual phenotypes observed in addiction." @default.
- W3143731966 created "2021-04-13" @default.
- W3143731966 creator A5032584985 @default.
- W3143731966 creator A5081844355 @default.
- W3143731966 creator A5091839051 @default.
- W3143731966 date "2021-03-01" @default.
- W3143731966 modified "2023-10-16" @default.
- W3143731966 title "Different Effects of Alcohol Exposure on Action and Outcome-Related Orbitofrontal Cortex Activity" @default.
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- W3143731966 doi "https://doi.org/10.1523/eneuro.0052-21.2021" @default.
- W3143731966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8174034" @default.
- W3143731966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33785522" @default.
- W3143731966 hasPublicationYear "2021" @default.
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