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- W3143743541 abstract "Objective:To explore the mechanism of the opening of blood brain barrier induced by thrombin (TM). Methods:Brain microvascular endothelial cells were cultured in vitro . After thrombin or thrombin+cathepsin G was added into the medium,the changes in the morphology of endothelial cell were dynmatically observed with phase contrast light microscopy and the expression of matrix metalloproteinase 2 (MMP 2) was measured with immuohistochemical method. Results:Cells began to contract after thrombin incubation, resulting in increased intercellular spaces and reduced cell areas. Cell contraction was time dependent. By 12 h after thrombin incubation , the area of cell was only 20 percent of that before treatment. The expression of MMP 2 was markedly increased compared with control group( P 0.01).After thrombin+cathepsin G incubation, the morphology and MMP 2 expression of cells had no significant difference compared with control group( P 0.05). Conclusion: Thrombin might induce endothelial cell contraction and promote MMP 2 expression by activating protease activated receptor 1 (PAR 1),and this may be the mechanism of BBB opening induced by thrombin. [" @default.
- W3143743541 created "2021-04-13" @default.
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- W3143743541 date "2003-01-01" @default.
- W3143743541 modified "2023-09-25" @default.
- W3143743541 title "Effect of thrombin on brain microvascular endothelial cell in vitro" @default.
- W3143743541 hasPublicationYear "2003" @default.
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