FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3143751331> ?p ?o ?g. }

• W3143751331 abstract "Abstract Background Cattle are ideally suited to investigate the genetics of male fertility. Semen from individual bulls is used for thousands of artificial inseminations for which the fertilization success is monitored. Results from the breeding soundness examination and repeated observations of semen quality complement the fertility evaluation for each bull. Results In a cohort of 3881 Brown Swiss bulls that had genotypes at 683,609 SNPs, we reveal four novel recessive QTL for male fertility on BTA1, 18, 25, and 26 using haplotype-based association testing. A QTL for bull fertility on BTA1 is also associated with sperm head shape anomalies. All other QTL are not associated with any of the semen quality traits investigated. We perform complementary fine-mapping approaches using publicly available transcriptomes as well as whole-genome sequencing data of 125 Brown Swiss bulls to reveal candidate causal variants. We show that missense or nonsense variants in SPATA16 , VWA3A, ENSBTAG00000006717 and ENSBTAG00000019919 are in linkage disequilibrium with the QTL. Using whole-genome sequence data, we detect strong association ( P = 4.83 × 10 − 12 ) of a missense variant (p.Ile193Met) in SPATA16 with male fertility. However, non-coding variants exhibit stronger association at all QTL suggesting that variants in regulatory regions contribute to variation in bull fertility. Conclusion Our findings in a dairy cattle population provide evidence that recessive variants may contribute substantially to quantitative variation in male fertility in mammals. Detecting causal variants that underpin variation in male fertility remains difficult because the most strongly associated variants reside in poorly annotated non-coding regions." @default.
• W3143751331 created "2021-04-13" @default.
• W3143751331 creator A5000493727 @default.
• W3143751331 creator A5035288434 @default.
• W3143751331 creator A5039170720 @default.
• W3143751331 creator A5051074850 @default.
• W3143751331 creator A5069507864 @default.
• W3143751331 creator A5083607078 @default.
• W3143751331 date "2021-03-30" @default.
• W3143751331 modified "2023-10-06" @default.
• W3143751331 title "Autosomal recessive loci contribute significantly to quantitative variation of male fertility in a dairy cattle population" @default.
• W3143751331 cites W1963534839 @default.
• W3143751331 cites W1968790784 @default.
• W3143751331 cites W1970285941 @default.
• W3143751331 cites W1971448442 @default.
• W3143751331 cites W1989646579 @default.
• W3143751331 cites W1997751006 @default.
• W3143751331 cites W2001985963 @default.
• W3143751331 cites W2002296556 @default.
• W3143751331 cites W2006300454 @default.
• W3143751331 cites W2014597803 @default.
• W3143751331 cites W2015275575 @default.
• W3143751331 cites W2033151532 @default.
• W3143751331 cites W2034992526 @default.
• W3143751331 cites W2038806680 @default.
• W3143751331 cites W2053284947 @default.
• W3143751331 cites W2056886869 @default.
• W3143751331 cites W2072953814 @default.
• W3143751331 cites W2074906381 @default.
• W3143751331 cites W2077763475 @default.
• W3143751331 cites W2078338257 @default.
• W3143751331 cites W2096060324 @default.
• W3143751331 cites W2096358713 @default.
• W3143751331 cites W2098143048 @default.
• W3143751331 cites W2099085143 @default.
• W3143751331 cites W2100683912 @default.
• W3143751331 cites W2103566275 @default.
• W3143751331 cites W2104554782 @default.
• W3143751331 cites W2104628102 @default.
• W3143751331 cites W2105020653 @default.
• W3143751331 cites W2108654230 @default.
• W3143751331 cites W2112546052 @default.
• W3143751331 cites W2126388623 @default.
• W3143751331 cites W2127322768 @default.
• W3143751331 cites W2130406585 @default.
• W3143751331 cites W2136735973 @default.
• W3143751331 cites W2136933352 @default.
• W3143751331 cites W2138345444 @default.
• W3143751331 cites W2140164632 @default.
• W3143751331 cites W2146771945 @default.
• W3143751331 cites W2156632388 @default.
• W3143751331 cites W2168133698 @default.
• W3143751331 cites W2197819633 @default.
• W3143751331 cites W2226451491 @default.
• W3143751331 cites W2284239065 @default.
• W3143751331 cites W2323326409 @default.
• W3143751331 cites W2338710066 @default.
• W3143751331 cites W2417483443 @default.
• W3143751331 cites W2523032102 @default.
• W3143751331 cites W2605987559 @default.
• W3143751331 cites W2606301281 @default.
• W3143751331 cites W2742843529 @default.
• W3143751331 cites W2766372106 @default.
• W3143751331 cites W2766752943 @default.
• W3143751331 cites W2793827201 @default.
• W3143751331 cites W2804822363 @default.
• W3143751331 cites W2886084239 @default.
• W3143751331 cites W2895695101 @default.
• W3143751331 cites W2901034260 @default.
• W3143751331 cites W2901865939 @default.
• W3143751331 cites W2936956377 @default.
• W3143751331 cites W2944382053 @default.
• W3143751331 cites W2950222708 @default.
• W3143751331 cites W2950866894 @default.
• W3143751331 cites W2951912016 @default.
• W3143751331 cites W2952113787 @default.
• W3143751331 cites W2954439798 @default.
• W3143751331 cites W2973156919 @default.
• W3143751331 cites W2974432505 @default.
• W3143751331 cites W2982078428 @default.
• W3143751331 cites W3000372303 @default.
• W3143751331 cites W3006222619 @default.
• W3143751331 cites W3007215937 @default.
• W3143751331 cites W3011183076 @default.
• W3143751331 cites W3018442141 @default.
• W3143751331 cites W3022309923 @default.
• W3143751331 cites W3025403624 @default.
• W3143751331 cites W3027341723 @default.
• W3143751331 cites W3040107810 @default.
• W3143751331 cites W3048576052 @default.
• W3143751331 cites W4232909036 @default.
• W3143751331 cites W4239039223 @default.
• W3143751331 doi "https://doi.org/10.1186/s12864-021-07523-3" @default.
• W3143751331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8010996" @default.
• W3143751331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33784962" @default.
• W3143751331 hasPublicationYear "2021" @default.
• W3143751331 type Work @default.
• W3143751331 sameAs 3143751331 @default.
• W3143751331 citedByCount "15" @default.
• W3143751331 countsByYear W31437513312021 @default.

• next